Evidence map›Paper›PMID 28557859›Full record

ArticleJournal of strength and conditioning research2017

Beta-2 Adrenergic Receptor Genotype Influences Power Output in Healthy Subjects.

Eli F Kelley, Bruce D Johnson, Eric M Snyder

Open access · greenAbstract read
In one paragraph

Article in Journal of strength and conditioning research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Influence of βClinical Medicine Insights. Cardiology · 2022
    Article
  2. Influence of βRespiratory research · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eli F Kelley1University of Minnesota, Minneapolis, Minnesota; and 2Mayo Clinic, Rochester, Minnesota.
Bruce D Johnson
Eric M Snyder
University of Minnesota · USMayo Clinic · US

Funding

Gene-by-Gene Interactions and Lung Fluid Balance in Patients with Heart FailureR01HL108962 · NHLBI · UNIVERSITY OF MINNESOTA · PI SNYDER, ERIC M · 2011 to 2016
$2.2M
NHLBI NIH HHS R01 HL108962
6 · The paper itself

Abstract

Kelley, EF, Johnson, BD, and Snyder, EM. Beta-2 adrenergic receptor genotype influences power output in healthy subjects. J Strength Cond Res 31(8): 2053-2059, 2017-The purpose of this study was to determine the effects of ADRB2 genotypes on muscle function (absolute power and relative power) in healthy subjects. We performed genotyping of the ADRB2 (amino acid 16) and high-intensity, steady-state exercise on 77 healthy subjects (AA = 18, AG = 25, GG = 34). There were no differences between genotype groups in age, height, weight, or body mass index (BMI) (age = 28.9 ± 5.7 years, 27.9 ± 5.7 years, 29.2 ± 5.9 years, height = 170.7 ± 8.6 cm, 174.9 ± 8.7 cm, 173.4 ± 9.6 cm, weight = 68.5 ± 13.0 kg, 75.0 ± 12.9 kg, 74.4 ± 12.9 kg, and BMI = 23.4 ± 3.9, 24.4 ± 2.9, 24.7 ± 3.4, for AA, AG, and GG, respectively). The genotype groups differed significantly in watts, and watts/V[Combining Dot Above]O2 with heavy exercise (watts = 186.3 ± 54.6, 237.8 ± 54.4, 219.4 ± 79.5, watts/V[Combining Dot Above]O2 = 0.08 ± 0.006, 0.09 ± 0.005, 0.08 ± 0.006). There was a trend toward significance (p = 0.058) for W·kg (2.7 ± 0.4, 3.2 ± 0.5, 2.9 ± 0.8, for AA, AG, and GG, respectively). These data suggest that genetic variation of the ADRB2 may influence relative strength in healthy subjects and may become an important genetic determinant of muscular strength and functional capacity in patients with diseases that result in a loss of muscle strength.

Indexed as

AdultBody Mass IndexBody WeightExerciseFemaleGenotypeHealthy VolunteersHumansMaleMuscle, SkeletalMuscle StrengthOxygen ConsumptionPolymorphism, Single NucleotideReceptors, Adrenergic, beta-2Young AdultADRB2 protein, humanReceptors, Adrenergic, beta-2

Identifiers

PMID28557859
PMCPMC5522357
OpenAlexW2618996702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.