ArticlePediatrics2017
Influenza Vaccine Effectiveness Against Pediatric Deaths: 2010-2014.
Article in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03277703 (Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- [Efficacy and safety of pediatric flu vaccination: a systematic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Pooled it
- Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Narrative Reminder Recall to Improve Pediatric Influenza Vaccination: A Pilot Randomized Clinical Trial.JAMA network open · 2026Trial
- Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine in children and adolescents 6 months through 17 years of age in India.Human vaccines & immunotherapeutics · 2022Trial
- Text Message Reminders for the Second Dose of Influenza Vaccine for Children: An RCT.Pediatrics · 2022Trial
- A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.Pediatric blood & cancer · 2020Trial
- Vaccine hesitancy and influenza beliefs among parents of children requiring a second dose of influenza vaccine in a season: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) study.Human vaccines & immunotherapeutics · 2020Trial
- Quadrivalent Influenza Vaccine Prevents Illness and Reduces Healthcare Utilization Across Diverse Geographic Regions During Five Influenza Seasons: A Randomized Clinical Trial.The Pediatric infectious disease journal · 2020Trial
- Influenza Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department or Urgent Care Encounters Among Children and Adults-VISION, United States, 2024-2025 Season.Open forum infectious diseases · 2026Article
- Saving children's lives through science and public health: winning the war against misinformation. The Society for Pediatric Research's 2026 Douglas K. Richardson Award presentation.Pediatric research · 2026Article
- Influenza vaccine effectiveness against influenza-associated hospitalizations and emergency department or urgent care encounters among children and adults - United States, 2024-25 season.medRxiv : the preprint server for health sciences · 2026Article
- Influenza Vaccine Effectiveness Among Children With and Without Underlying Conditions.Pediatrics · 2026Article
- Mapping Pediatric Seasonal Influenza Vaccine Safety and Immunogenicity Evidence: A Systematic Review of Clinical Trials.Vaccines · 2025Review
- Parental Knowledge, Awareness, and Attitudes Toward Seasonal Influenza Vaccination in Al-Madinah, Saudi Arabia: A Cross-Sectional Study.International journal of environmental research and public health · 2025Article
- Reports of Encephalopathy Among Children with Influenza-Associated Mortality - United States, 2010-11 Through 2024-25 Influenza Seasons.MMWR. Morbidity and mortality weekly report · 2025Article
- Clinical Profile, Intensive Care Needs and Predictors of Outcome Among Children Admitted with Non-COVID Severe Acute Respiratory Illness (SARI) During the Pandemic.Indian journal of pediatrics · 2024Article
- Optimal timing of influenza vaccination in young children: population based cohort study.BMJ (Clinical research ed.) · 2024Article
- Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles.Frontiers in immunology · 2024Article
- Characteristics and outcome of influenza-associated encephalopathy/encephalitis among children in China.Clinics (Sao Paulo, Brazil) · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
BACKGROUND AND
objectivesSurveillance for laboratory-confirmed influenza-associated pediatric deaths since 2004 has shown that most deaths occur in unvaccinated children. We assessed whether influenza vaccination reduced the risk of influenza-associated death in children and adolescents.
methodsWe conducted a case-cohort analysis comparing vaccination uptake among laboratory-confirmed influenza-associated pediatric deaths with estimated vaccination coverage among pediatric cohorts in the United States. Case vaccination and high-risk status were determined by case investigation. Influenza vaccination coverage estimates were obtained from national survey data or a national insurance claims database. We estimated odds ratios from logistic regression comparing odds of vaccination among cases with odds of vaccination in comparison cohorts. We used Bayesian methods to compute 95% credible intervals (CIs) for vaccine effectiveness (VE), calculated as (1 - odds ratio) × 100.
resultsFrom July 2010 through June 2014, 358 laboratory-confirmed influenza-associated pediatric deaths were reported among children aged 6 months through 17 years. Vaccination status was determined for 291 deaths; 75 (26%) received vaccine before illness onset. Average vaccination coverage in survey cohorts was 48%. Overall VE against death was 65% (95% CI, 54% to 74%). Among 153 deaths in children with underlying high-risk medical conditions, 47 (31%) were vaccinated. VE among children with high-risk conditions was 51% (95% CI, 31% to 67%), compared with 65% (95% CI, 47% to 78%) among children without high-risk conditions.
conclusionsInfluenza vaccination was associated with reduced risk of laboratory-confirmed influenza-associated pediatric death. Increasing influenza vaccination could prevent influenza-associated deaths among children and adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.