Evidence map›Paper›PMID 28557357›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme-Catalytic Hairpin Assembly Probe.

Zhenkun Wu, Huanhuan Fan, Nitya Sai Reddy Satyavolu, WenJing Wang, Ryan Lake, Jian-Hui Jiang, Yi Lu

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Light-Inducible Bispecific DNAzymes Reveal Mitochondrial FeAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Amplified Production of a DNA Decoy Catalyzed by Intracellular MicroRNA.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Construction and Application of DNAzyme-based Nanodevices.Chemical research in Chinese universities · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhenkun WuState Key Laboratory of Chemeo/Bio-Sensing and Chemometrics Institute of Chemical Biology and Nanomedicine and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Huanhuan FanState Key Laboratory of Chemeo/Bio-Sensing and Chemometrics Institute of Chemical Biology and Nanomedicine and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Nitya Sai Reddy SatyavoluDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
WenJing WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Ryan LakeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Jian-Hui JiangState Key Laboratory of Chemeo/Bio-Sensing and Chemometrics Institute of Chemical Biology and Nanomedicine and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Yi LuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.ORCID 0000-0003-1221-6709

Funding

Novel DNAzyme sensors for lithium and sodium to understand cellular and molecular mechanisms of lithium treatment of bipolar disorderR21MH110975 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LU, YI · 2016 to 2017
$401k
NIMH NIH HHS R21 MH110975
6 · The paper itself

Abstract

DNAzymes are a promising platform for metal ion detection, and a few DNAzyme-based sensors have been reported to detect metal ions inside cells. However, these methods required an influx of metal ions to increase their concentrations for detection. To address this major issue, the design of a catalytic hairpin assembly (CHA) reaction to amplify the signal from photocaged Na

Indexed as

Optical ImagingBiocatalysisDNA, CatalyticFluorescent DyesHeLa CellsHumansIonsSodiumSpectrometry, FluorescenceDNA, CatalyticFluorescent DyesIonsSodiumbiosensorsDNAzymesnucleic acid amplificationphotoactivation

Identifiers

PMID28557357
PMCPMC5814595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.