Evidence map›Paper›PMID 28557148›Full record

Trial reportPediatric transplantation2017

The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study.

P S Verghese, D O Schmeling, E A Filtz, A J Matas, H H Balfour

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

P S VergheseDepartment of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-8836-0881
D O SchmelingLaboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA.
E A FiltzLaboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA.
A J MatasSurgery, University of Minnesota Medical Center, Minneapolis, MN, USA.
H H BalfourDepartment of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN, USA.

Funding

Viral Infections and Posttransplant MorbidityP01DK013083 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MATAS, ARTHUR J · 1986 to 2013
$14.9M
NIDDK NIH HHS P01 DK013083
6 · The paper itself

Abstract

We previously demonstrated that detectable BKV replication in donor urine pretransplant was significantly associated with post-transplant recipient BKV viremia. In this 4-year prospective study, we assessed whether recipient BKV replication pretransplant was associated with post-transplant viremia/BKV nephropathy. We studied 220 primary adult and pediatric organ transplant recipients for 490 person-years and 2100 clinical visits. BKV viruria was detectable in 28 (16%), 26 adults and two children; and viremia in none pretransplant. Post-transplant viruria occurred in all recipients with pretransplant BKV viruria, significantly more than in recipients without pretransplant viruria on univariate (P<.005) and multivariate analysis including type of organ transplanted and immunosuppression type (P .008). Time to post-transplant viruria was significantly shorter in recipients with pretransplant viruria (P .01). By univariate and multivariate analysis, BKV viruria in recipients pretransplant did not impact post-transplant BKV viremia (P=.97 and .97, respectively) even when stratified by type of organ transplant (kidney P=.6; liver P=.5). The peak serum and urine BKV PCR post-transplant were not significantly different in patients with pretransplant BKV viruria and no one developed BK nephropathy. In conclusion, recipient BKV viruria prior to transplant predicts post-transplant viruria but not viremia or BKV nephropathy.

Indexed as

Organ TransplantationAdolescentAdultAgedBiomarkersBK VirusChildChild, PreschoolDNA, ViralFemaleFollow-Up StudiesHumansInfantKidney DiseasesMaleMiddle AgedBiomarkersDNA, ViralBK nephropathyBK viruriaBK virusvirus

Identifiers

PMID28557148
PMCPMC5511090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.