ArticlePsycho-oncology2018
Effect of androgen deprivation therapy on sexual function and bother in men with prostate cancer: A controlled comparison.
Article in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Ejaculatory function after radiotherapy for prostate cancer: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2025Pooled it
- Quality of Nursing Care: Addressing Sexuality as Part of Prostate Cancer Management, an Umbrella Review.Journal of advanced nursing · 2025Pooled it
- Pooled it
- Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Pooled it
- Marital status and perceived stress in men with advanced prostate cancer: A randomized-controlled trial of cognitive behavioral stress management.Journal of psychosomatic research · 2023Trial
- Salvage Androgen Deprivation Therapy Use After Definitive Radiotherapy With vs Without Androgen Deprivation Therapy in Prostate Cancer.The Prostate · 2026Article
- Erectile Dysfunction and Its Impact on Health-Related Quality of Life in Prostate Cancer Patients: A Multicenter Cross-Sectional Study from Pakistan.Epidemiologia (Basel, Switzerland) · 2026Article
- Symptom cluster profiles and their impact on quality of life in Chinese patients with prostate cancer undergoing ADT: a cross-sectional study.Frontiers in oncology · 2026Article
- High-risk biochemical recurrence in prostate cancer: identification and early intervention strategies.Frontiers in urology · 2026Review
- Psychological Involvement in the Journey of a Patient with Localized Prostate Cancer-From Diagnosis to Treatment.Diseases (Basel, Switzerland) · 2025Article
- Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL.Oncology and therapy · 2025Article
- Impact of neoadjuvant relugolix on patient-reported sexual function and bother.Frontiers in oncology · 2024Article
- Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy.Journal of behavioral medicine · 2022Article
- Hormone-Dependent Tumors and Sexuality in the Neuro-Oncology of Women (N.O.W.): Women's Brain Tumors, Gaps in Sexuality Considerations, and a Need for Evidence-Based Guidelines.Current oncology reports · 2021Review
- Androgen receptors in areas of the spinal cord and brainstem: A study in adult male cats.Journal of anatomy · 2021Article
- Men's sexual help-seeking and care needs after radical prostatectomy or other non-hormonal, active prostate cancer treatments.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer.JNCI cancer spectrum · 2020Article
- Preliminary exploration of clinical factors affecting acute toxicity and quality of life after carbon ion therapy for prostate cancer.Radiation oncology (London, England) · 2019Article
- Mood, sexuality, and relational intimacy after starting androgen deprivation therapy: implications for couples.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance.Endocrine reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe adverse sexual effects of androgen deprivation therapy (ADT) on men with prostate cancer have been well described. Less well known is the relative degree of sexual dysfunction and bother associated with ADT compared to other primary treatment modalities such as radical prostatectomy. We sought to describe the trajectory and relative magnitude of changes in sexual function and bother in men on ADT and to examine demographic and clinical predictors of ADT's adverse sexual effects.
methodsProstate cancer patients treated with ADT (n = 60) completed assessments of sexual function and sexual bother 3 times during a 1-year period after the initiation of ADT. Prostate cancer patients treated with radical prostatectomy only and not receiving ADT (n = 85) and men with no history of cancer (n = 86) matched on age and education completed assessments at similar intervals.
resultsAndrogen deprivation therapy recipients reported worsening sexual function and increasing bother over time compared to controls. Effect sizes for the differences in sexual function were large to very large, and for bother were small to very large. Age younger than 83 years predicted relatively poorer sexual function, and age younger than 78 years predicted greater sexual bother at 12 months in men on ADT compared to men not on ADT.
conclusionsMost men on ADT for prostate cancer will never return to baseline levels of sexual function. Interventions focused on sexual bother over function and designed to help couples build and maintain satisfying relationship intimacy are likely to more positively affect men's psychological well-being while on ADT than medical or sexual aids targeting sexual dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.