Evidence map›Paper›PMID 28556945›Full record

ArticleJournal of neuroscience research2017

Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.

Nathan L Davidson, Fengshan Yu, Naruchorn Kijpaisalratana, Tuan Q Le, Laurel A Beer, Kryslaine L Radomski, Regina C Armstrong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nathan L DavidsonProgram in Neuroscience, Bethesda, Maryland, USA.
Fengshan YuDepartment of Anatomy, Physiology, and Genetics, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA.
Naruchorn KijpaisalratanaDepartment of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tuan Q LeDepartment of Anatomy, Physiology, and Genetics, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA.
Laurel A BeerDepartment of Anatomy, Physiology, and Genetics, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA.
Kryslaine L RadomskiDepartment of Anatomy, Physiology, and Genetics, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA.ORCID 0000-0001-9624-623X
Regina C ArmstrongProgram in Neuroscience, Bethesda, Maryland, USA.ORCID 0000-0001-7296-6750
Uniformed Services University of the Health Sciences · USChulalongkorn University · THNation University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemia/lymphoma-related factor (LRF), a zinc-finger transcription factor encoded by Zbtb7a, is a protooncogene that regulates differentiation in diverse cell lineages, and in the CNS, its function is relatively unexplored. This study is the first to examine the role of LRF in CNS pathology. We first examined LRF expression in a murine viral model of spinal cord demyelination with clinically relevant lesion characteristics. LRF was rarely expressed in oligodendrocyte progenitors (OP) yet, was detected in nuclei of the majority of oligodendrocytes in healthy adult CNS and during remyelination. Plp/CreER

Indexed as

AnimalsCell DifferentiationCell LineageDNA-Binding ProteinsFemaleGene Expression RegulationMiceMice, Inbred C57BLOligodendrogliaRemyelinationTranscription FactorsDNA-Binding ProteinsTranscription FactorsZbtb7a protein, mousecuprizonedemyelinationdifferentiationnotcholigodendrocyte progenitor

Identifiers

PMID28556945
PMCPMC5655903
OpenAlexW2619345889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.