Evidence map›Paper›PMID 28556799›Full record

ArticleInternational journal of molecular sciences2017

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR

Andras Franko, Alexander Kunze, Marlen Böse, Jürgen-Christoph von Kleist-Retzow, Mats Paulsson, Ursula Hartmann, Rudolf J Wiesner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andras FrankoInstitute of Vegetative Physiology, Medical Faculty, University of Köln, Robert-Koch-Str. 39, D-50931 Cologne, Germany. andras.franko@med.uni-tuebingen.de.
Alexander KunzeCenter for Biochemistry, Medical Faculty, University of Köln, Joseph-Stelzmann-Str. 52, D-50931 Cologne, Germany. alexander-kunze@gmx.net.
Marlen BöseInstitute of Vegetative Physiology, Medical Faculty, University of Köln, Robert-Koch-Str. 39, D-50931 Cologne, Germany. marlen.b@gmx.net.
Jürgen-Christoph von Kleist-RetzowInstitute of Vegetative Physiology, Medical Faculty, University of Köln, Robert-Koch-Str. 39, D-50931 Cologne, Germany. juergen-christoph.von-kleist-retzow@uk-koeln.de.
Mats PaulssonCenter for Biochemistry, Medical Faculty, University of Köln, Joseph-Stelzmann-Str. 52, D-50931 Cologne, Germany. mats.paulsson@uni-koeln.de.
Ursula HartmannCenter for Biochemistry, Medical Faculty, University of Köln, Joseph-Stelzmann-Str. 52, D-50931 Cologne, Germany. ursula.hartmann@uni-koeln.de.
Rudolf J WiesnerInstitute of Vegetative Physiology, Medical Faculty, University of Köln, Robert-Koch-Str. 39, D-50931 Cologne, Germany. rudolf.wiesner@uni-koeln.de.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria play a pivotal role in energy metabolism, but whether insulin signaling per se could regulate mitochondrial function has not been identified yet. To investigate whether mitochondrial function is regulated by insulin signaling, we analyzed muscle and liver of insulin receptor (IR)

Indexed as

AnimalsBlood GlucoseGlucoseInsulinInsulin Receptor Substrate ProteinsLiverMiceMitochondriaMuscle, SkeletalReceptor, InsulinSignal TransductionBlood GlucoseGlucoseInsulinInsulin Receptor Substrate ProteinsReceptor, Insulinglucose metabolisminsulin receptorinsulin receptor substrate 1insulin signalinglivermitochondriaskeletal muscle

Identifiers

PMID28556799
PMCPMC5485980
OpenAlexW2618535506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.