Trial reportJournal of psychiatry & neuroscience : JPN2017
Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Pooled it
- Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals.Molecular psychiatry · 2021Trial
- Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Investigating neural impairments in psychotic disorders using electroencephalography and cortical spheroids.Translational psychiatry · 2026Article
- Mismatch Negativity (MMN) as a Pharmacodynamic/Response Biomarker for NMDA Receptor and Excitatory/Inhibitory Imbalance-Targeted Treatments in Schizophrenia.Advances in neurobiology · 2024Review
- Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.International journal of molecular sciences · 2023Article
- The Altered States Database: Psychometric data from a systematic literature review.Scientific data · 2022Article
- The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [Journal of psychopharmacology (Oxford, England) · 2022Article
- Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis.Journal of psychiatric research · 2021Article
- Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway.Scientific reports · 2021Article
- Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System.Frontiers in psychiatry · 2021Article
- Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia.Frontiers in neuroscience · 2021Review
- A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms.Frontiers in cell and developmental biology · 2021Review
- mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia.Human brain mapping · 2020Article
- Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques.Frontiers in neuroscience · 2020Review
- Interaction of Background Noise and Auditory Hallucinations on Phonemic Mismatch Negativity (MMN) and P3a Processing in Schizophrenia.Frontiers in psychiatry · 2020Article
- Article
- Selective Prefrontal Disinhibition in a Roving Auditory Oddball Paradigm Under N-Methyl-D-Aspartate Receptor Blockade.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Stephanie ThiebesFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Gregor LeichtFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Stjepan CuricFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Saskia SteinmannFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Nenad PolomacFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Christina AndreouFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Iris EichlerFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Lars EichlerFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Christian ZöllnerFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Jürgen GallinatFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Ileana Hanganu-OpatzFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Christoph MulertFrom the Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Thiebes, Leicht, Curic, Steinmann, Polomac, Andreou, Mulert); the Center for Gender Research and Early Detection, University of Basel Psychiatric Clinics, Basel, Switzerland (Andreou); the Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Eichler, Zöllner); the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Gallinat); and the Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Hanganu-Opatz).
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Basel · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTargeting the
methodsWe examined the impact of ketamine during an MMN paradigm with 64-channel electroencephalography (EEG) and assessed the psychopathological status using the Positive and Negative Syndrome Scale (PANSS) in healthy male volunteers using a single-blind, randomized, placebo-controlled crossover design. Low-resolution brain electromagnetic tomography was used for source localization.
resultsTwenty-four men were included in our analysis. Significant reductions of MMN amplitudes and an increase in all PANSS scores were identified under the ketamine condition. Smaller MMN amplitudes were specifically associated with more pronounced negative symptoms. Source analysis of MMN generators indicated a significantly reduced current source density (CSD) under the ketamine condition in the primary auditory cortex, the posterior cingulate and the middle frontal gyrus. LIMITATIONS: The sample included only men within a tight age range of 20-32 years.
conclusionThe MMN might represent a biomarker for negative symptoms in schizophrenia related to an insufficient NMDAR system and could be used to identify patients with schizophrenia with negative symptoms due to NMDAR dysfunction.
Indexed as
AdultBrainEvoked Potentials, AuditoryExcitatory Amino Acid AntagonistsGlutamic AcidHealthy VolunteersHumansKetamineMaleReceptors, N-Methyl-D-AspartateSchizophreniaSingle-Blind MethodYoung AdultExcitatory Amino Acid AntagonistsGlutamic AcidKetamineReceptors, N-Methyl-D-Aspartate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.