ArticleBiotechnology progress2017
Characterizing the impact of pressure on virus filtration processes and establishing design spaces to ensure effective parvovirus removal.
Article in Biotechnology progress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Downstream Purification Strategies for Virus-like Particles: A Systematic Review of Structure Preservation, Impurity Control, and Viral Safety.Microorganisms · 2026Review
- Development of a Small-Scale Continuous Virus Filtration Model That Incorporates Inline Spiking and Mixing.Biotechnology and bioengineering · 2025Article
- Advances in purification of SARS-CoV-2 spike ectodomain protein using high-throughput screening and non-affinity methods.Scientific reports · 2022Article
- Filter made of cuprammonium regenerated cellulose for virus removal: a mini-review.Cellulose (London, England) · 2022Review
- Analysis of filtration behavior using integrated column chromatography followed by virus filtration.Biotechnology and bioengineering · 2021Article
- The design basis for the integrated and continuous biomanufacturing framework.Biotechnology and bioengineering · 2021Article
- Advances in Purification of SARS-CoV-2 Spike Ectodomain Protein Using High-Throughput Screening and Non-Affinity Methods.Research square · 2021Article
- A common framework for integrated and continuous biomanufacturing.Biotechnology and bioengineering · 2021Review
- Development of small-scale models to understand the impact of continuous downstream bioprocessing on integrated virus filtration.Biotechnology progress · 2020Article
- Microscopic visualization of virus removal by dedicated filters used in biopharmaceutical processing: Impact of membrane structure and localization of captured virus particles.Biotechnology progress · 2019Article
- Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions.Biotechnology progressArticle
- Evaluating the impact of ionic strength on retention of minute virus of mice during small virus-retentive filtration.Biotechnology progressArticle
- A design space for the filtration of challenging monoclonal antibodies using Planova™ S20N, a new regenerated cellulose virus removal filter.Biotechnology progressArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus filtration provides robust removal of potential viral contaminants and is a critical step during the manufacture of biotherapeutic products. However, recent studies have shown that small virus removal can be impacted by low operating pressure and depressurization. To better understand the impact of these conditions and to define robust virus filtration design spaces, we conducted multivariate analyses to evaluate parvovirus removal over wide ranges of operating pressure, solution pH, and conductivity for three mAb products on Planova™ BioEX and 20N filters. Pressure ranges from 0.69 to 3.43 bar (10.0-49.7 psi) for Planova BioEX filters and from 0.50 to 1.10 bar (7.3 to 16.0 psi) for Planova 20N filters were identified as ranges over which effective removal of parvovirus is achieved for different products over wide ranges of pH and conductivity. Viral clearance at operating pressure below the robust pressure range suggests that effective parvovirus removal can be achieved at low pressure but that Minute virus of mice (MVM) logarithmic reduction value (LRV) results may be impacted by product and solution conditions. These results establish robust design spaces for Planova BioEX and 20N filters where high parvovirus clearance can be expected for most antibody products and provide further understanding of viral clearance mechanisms. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1294-1302, 2017.
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