ArticleJournal of diabetes investigation2018
Low glycated hemoglobin level is associated with severity of frailty in Japanese elderly diabetes patients.
Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Risk Prediction Model for Frailty in Older Chinese Patients With Type 2 Diabetes Mellitus: A Systematic Review.Geriatrics & gerontology international · 2026Pooled it
- Prevalence and risk factors of frailty in older adults with diabetes: A systematic review and meta-analysis.PloS one · 2024Pooled it
- The Clinical Frailty Scale (CFS) employment in the frailty assessment of patients suffering from Non-Communicable Diseases (NCDs): A systematic review.Frontiers in medicine · 2022Pooled it
- Pooled it
- Feasibility of glycated haemoglobin target-setting in adults with diabetes: A mixed-methods study.PloS one · 2026Trial
- Trial
- Serum Periostin as a Complementary Biomarker of Frailty in Type 2 Diabetes: A Pilot Study Using the FRAIL Scale.International journal of molecular sciences · 2026Article
- Examining HbA1c in Frail Older Adults: A Linked Data Cohort Study.Australasian journal on ageing · 2026Article
- Multidimensional associations of physical performance, balance, wellness and daily activities with frailty in older adults with coexisting frailty and diabetes.Journal of clinical nursing · 2026Article
- Anti-aging effects of the adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanisms of action and beneficial effects in older people.Endocrine journal · 2026Review
- Relationship between berry intake and frailty in the elderly and the mediating role of six blood markers: based on Chinese and American studies.Frontiers in nutrition · 2026Article
- Glycated hemoglobin (A1c) values and antidiabetic treatment deprescription in hospitalized nonagenarians with type 2 diabetes.Frontiers in public health · 2026Article
- Frailty progression before and after diabetes onset among older adults in china: a nationwide cohort study.BMC geriatrics · 2025Article
- Practical Considerations in the Management of Frail Older People with Diabetes.Diseases (Basel, Switzerland) · 2025Review
- Metformin reduces the risk of frailty: evidence from a Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Construction and Verification of a Frailty Risk Prediction Model for Elderly Patients with Coronary Heart Disease Based on a Machine Learning Algorithm.Reviews in cardiovascular medicine · 2025Article
- Development and Validation of Nomogram to Predict Frailty for Older Patients Undergoing Abdominal Surgery.Clinical interventions in aging · 2025Article
- Development and internal validation of an age less-dependent frailty score in the cardiovascular health study.Frontiers in medicine · 2025Article
- The association between oral frailty and HbA1c among older adults with T2DM: the chain mediating effect of nutritional status and physical frailty.European geriatric medicine · 2024Article
- Frailty Detection in Older Adults with Diabetes: A Scoping Review of Assessment Tools and Their Link to Key Clinical Outcomes.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionPreviously, a study using a narrowly defined (physical base) frailty scale reported that both good and bad (U-shaped curve) glycated hemoglobin (HbA1c) levels were frailty risk factors in patients with type 2 diabetes mellitus. However, no such studies in Japan have shown this. We aimed to evaluate the frailty risk factors including HbA1c in elderly Japanese patients with type 2 diabetes mellitus using a broadly defined (both physical and psychosocial base) frailty scale, the Clinical Frailty Scale (CFS). MATERIALS AND
methodsWe randomly enrolled 132 elderly patients with type 2 diabetes mellitus (aged ≥65 years) and categorized the patients into nine stages of frailty using CFS. Because no patient had CFS 9, patients with a CFS score of 1-4 and 5-8 were defined as non-frail and frail, respectively. We attempted to identify the risk factors of frailty by investigating the association between CFS stage and various patient factors.
resultsMultiple regression analysis showed that an increase in age, low levels of albumin, high-density lipoprotein cholesterol, systolic blood pressure, HbA1c, total cholesterol, and bodyweight were statistically significant and strong independent risk factors for frailty, suggesting that reverse metabolism owing to malnutrition in elderly type 2 diabetes mellitus patients might be involved.
conclusionsHbA1c level was not a U-shaped risk for frailty, suggesting that relatively good glycemic control might be more important for frailty than poor control in elderly type 2 diabetes mellitus patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.