ArticleGenes, brain, and behavior2017
A single bout of exercise increases hippocampal Bdnf: influence of chronic exercise and noradrenaline.
Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Comparative effects of moderate-intensity continuous training and high-intensity interval training on ADHD symptoms and behavioral inhibition in children.European journal of pediatrics · 2025Trial
- The impact of exercise on cognitive function and brain health across the lifespan: A systematic review.Ibrain · 2026Review
- Neuronal activity-induced GLUT3 plasma translocation supports energy demands for memory acquisition.Communications biology · 2025Article
- Neurobiological Synergy of Plant and Animal Sources of Omega-3 and Exercise in Aging: Implications for Molecular Signaling, Memory, Spatial Learning, and Brain Function.Food science & nutrition · 2025Review
- Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue.Frontiers in neuroscience · 2025Article
- Voluntary running partially prevents photoreceptor cell death in retinitis pigmentosa.Frontiers in neuroscience · 2025Article
- Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.PloS one · 2025Article
- Acute effects of different physical activity on executive function and regulation role of beta oscillation in sedentary youth frontal region.Scientific reports · 2024Article
- Effects of acute aerobic exercise on mnemonic discrimination performance in older adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- Effects of different exercise intensities of race-walking on brain functional connectivity as assessed by functional near-infrared spectroscopy.Frontiers in human neuroscience · 2022Article
- Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice.Journal of molecular neuroscience : MN · 2021Article
- A novel knockout mouse model of the noncoding antisenseHeliyon · 2021Article
- Review
- Exercise-Induced Elevated BDNF Level Does Not Prevent Cognitive Impairment Due to Acute Exposure to Moderate Hypoxia in Well-Trained Athletes.International journal of molecular sciences · 2020Article
- The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion.Molecular neurobiology · 2020Article
- Acute forced exercise increases Bdnf IV mRNA and reduces exploratory behavior in C57BL/6J mice.Genes, brain, and behavior · 2020Article
- Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.Frontiers in molecular neuroscience · 2020Article
- Post-fracture Rehabilitation Effects on Brain Function in Older People.Yonago acta medica · 2019Article
- Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session.Neural plasticity · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Research in human subjects suggests that acute exercise can improve memory performance, but the qualities of the exercise necessary to promote improved memory, and the signaling pathways that mediate these effects are unknown. Brain-derived neurotrophic factor (Bdnf), noradrenergic signaling, and post-translational modifications to AMPA receptors have all been implicated in the enhancement of memory following emotional or physical arousal; however, it is not known if a single bout of exercise is sufficient to engage these pathways. Here we use a rodent model to investigate the effects of acute and chronic exercise on hippocampal transcript-specific Bdnf expression and phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor. A single bout of treadmill exercise was insufficient to mimic the increased expression of GluR1 protein and phosphorylation at Ser845 observed following 1 month of voluntary wheel running. However, acute exercise was sufficient to increase Bdnf transcript IV messenger RNA (mRNA) expression in sedentary subjects, but not subjects housed for 1 month with a running wheel. High-intensity acute exercise increased total Bdnf mRNA in sedentary mice, but not above levels observed following chronic access to the running wheel. Although depletion of central noradrenergic signaling with DSP-4 reduced Bdnf IV mRNA, the effect of acute exercise on Bdnf mRNA persisted. Our characterization of the effects of acute exercise on Bdnf expression and persistence in the absence of noradrenergic modulation may inform strategies to employ physical activity to combat cognitive aging and mental health disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.