ArticleEuropean journal of neurology2017
Migraine associated with altitude: results from a population-based study in Nepal.
Article in European journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A Resting State Functional Magnetic Resonance Imaging Study in Migraine Without Aura in Middle and High Altitude Areas.Brain and behavior · 2025Article
- The prevalence of headache disorders in children and adolescents in Nepal: a schools-based cross-sectional study.The journal of headache and pain · 2025Article
- Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas.Frontiers in systems neuroscience · 2025Article
- Caffeine's Neuroprotective Effect on Memory Impairment: Suppression of Adenosine ACNS neuroscience & therapeutics · 2024Article
- [Temporal trend of the global prevalence rate of tension-type headache in children and adolescents in 1990-2021].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- The prevalence and demographic associations of headache in the adult population of Peru: a national cross-sectional population-based study.The journal of headache and pain · 2024Article
- Article
- The HARDSHIP databases: a forthcoming free good from the Global Campaign against Headache.The journal of headache and pain · 2023Article
- Prevalence of migraine and tension-type headache among undergraduate medical students of Kathmandu Valley: A cross-sectional study.Health science reports · 2022Article
- The Global Campaign turns 18: a brief review of its activities and achievements.The journal of headache and pain · 2022Review
- The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates.The journal of headache and pain · 2022Review
- Sleep loss effects on physiological and cognitive responses to systemic environmental hypoxia.Frontiers in physiology · 2022Review
- Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal.Cephalalgia : an international journal of headache · 2021Article
- Recommendations for traveling to altitude with neurological disorders.Journal of central nervous system disease · 2021Review
- Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus.Frontiers in neurology · 2021Review
- Prevalence of migraine and non-migraine headache and its relation with other diseases in the adults of Aseer Region, Saudi Arabia.Journal of family medicine and primary care · 2020Article
- Primary headache disorders among the adult population of Mongolia: prevalences and associations from a population-based survey.The journal of headache and pain · 2019Article
- Sherpas, Coca Leaves, and Planes: High Altitude and Airplane Headache Review with a Case of Post-LASIK Myopic Shift.Current neurology and neuroscience reports · 2019Review
- Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.Scientific reports · 2019Article
- Health-care utilization for headache disorders in Nepal: a population-based door-to-door survey.The journal of headache and pain · 2018Article
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5 authors.
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Abstract
background and purposeA 1988 pilot study in Peru suggested an association between migraine and chronic exposure to high altitude. This study provides epidemiological evidence corroborating this.
methodsIn a cross-sectional nationwide population-based study, a representative sample of Nepali-speaking adults were recruited through stratified multistage cluster sampling. They were visited at home by trained interviewers using a culturally adapted questionnaire. The altitude of dwelling of each participant was recorded.
resultsOf 2100 participants, over half [1100 (52.4%)] were resident above 1000 m and almost one quarter [470 (22.4%)] at ≥2000 m. Age- and gender-standardized migraine prevalence increased from 27.9% to 45.5% with altitude between 0 and 2499 m and thereafter decreased to 37.9% at ≥2500 m. The likelihood of having migraine was greater (odds ratio, 1.5-2.2; P ≤ 0.007) at all higher altitudes compared with <500 m. In addition, all symptom indices increased with altitude across the range <500 m to 2000-2499 m, i.e. median attack frequency from 1.3 to 3.0 days/month (P < 0.001), median duration from 9 to 24 h (P < 0.001) and pain intensity [the proportion reporting 'bad pain' (highest intensity)] from 35.5% to 56.9% (P = 0.011). Each of these showed a downward trend above 2500 m.
conclusionsDwelling at high altitudes increases not only migraine prevalence but also the severity of its symptoms.
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