ArticleTransfusion2017
Safety of acoustic separation in plastic devices for extracorporeal blood processing.
Article in Transfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Acoustofluidic-based therapeutic apheresis system.Nature communications · 2024Article
- Rosette-induced separation of T cells by acoustophoresis.Biomicrofluidics · 2022Article
- Focalization Performance Study of a Novel Bulk Acoustic Wave Device.Nanomaterials (Basel, Switzerland) · 2021Article
- Dielectrophoresis Separation of Platelets Using a Novel Zigzag Microchannel.Micromachines · 2020Article
- Microparticle Acoustophoresis in Aluminum-Based Acoustofluidic Devices with PDMS Covers.Micromachines · 2020Article
- Acoustofluidic separation of cells and particles.Microsystems & nanoengineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAcoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic format suitable for clinical applications. STUDY DESIGN AND
methodsWe developed a disposable, rectangular, polystyrene microchannel acoustic cell-separation system and applied acoustic energy relevant for plasmapheresis. Fresh blood from healthy volunteers was exposed in vitro to acoustic energy in an open microfluidic circuit with and without ultrasound applied. Blood was tested for perturbations in red blood cells, platelets, and coagulation using clinical assays.
resultsRed blood cell and platelet size parameters as well as coagulation activation all were within 3% of baseline values. P-selectin expression on platelets increased by an average of 10.9% relative to baseline. Hemolysis increased with flow through the microfluidic channel, but percentage hemolysis remained below 0.3%.
conclusionBlood parameters in a single-pass, microfluidic acoustic cell-separation apparatus remained within normal limits. In vivo animal studies that model continuous separation in a physiologic environment are warranted.
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Registered trials
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