Evidence map›Paper›PMID 28555657›Full record

ReviewNature reviews. Genetics2017

Associating cellular epigenetic models with human phenotypes.

Tuuli Lappalainen, John M Greally

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  13. Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
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  19. Environmental and Genetic Perturbations of the Sperm Epigenome.Advances in experimental medicine and biology · 2026
    Review
  20. Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tuuli LappalainenNew York Genome Center, 101 Avenue of the Americas, New York, New York 10013, USA; and at the Department of Systems Biology, Columbia University, 1130 Street Nicholas Avenue, New York, New York 10032, USA.
John M GreallyDepartments of Genetics, Medicine and Pediatrics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, New York 10461, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic association studies have been carried out to test the hypothesis that environmental perturbations trigger cellular reprogramming, with downstream effects on cellular function and phenotypes. There have now been numerous studies of the potential molecular mediators of epigenetic changes by epigenome-wide association studies (EWAS). However, a challenge for the field is the interpretation of the results obtained. We describe a second-generation EWAS approach, which focuses on the possible cellular models of epigenetic perturbations, studied by rigorous analysis and interpretation of genomic data. Thus refocused, epigenetics research aligns with the field of functional genomics to provide insights into environmental and genetic influences on phenotypic variation in humans.

Indexed as

Epigenesis, GeneticModels, GeneticPhenotypeAnimalsCellular ReprogrammingDiseaseDNA MethylationGenetic VariationGenome-Wide Association StudyHumansNeoplasmsTranscription FactorsTranscription Factors

Identifiers

PMID28555657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.