ArticleNature communications2017
Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 116 citations in OpenAlex.
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- Artificial light at night (ALAN) negatively affects expression of transcripts involved in biosynthesis of molting and juvenile hormones in Bombyx mori.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Clock-related neuropeptides inFrontiers in genetics · 2026Article
- Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity inbioRxiv : the preprint server for biology · 2025Article
- Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons.iScience · 2025Article
- Synaptic targets of circadian clock neurons influence core clock parameters.Science advances · 2025Article
- Photoperiodic plasticity of pigment-dispersing factor immunoreactive fibers projecting toward prothoracicotropic hormone neurons in flesh fly Sarcophaga similis larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters.bioRxiv : the preprint server for biology · 2025Article
- The circadian genes are required in DAL neurons forFrontiers in neuroscience · 2025Article
- Article
- Short neuropeptide F in integrated insect physiology.Journal of Zhejiang University. Science. B · 2024Review
- Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A dynamical model of growth and maturation inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
- Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures inInternational journal of molecular sciences · 2023Article
- BMAL1 Promotes Valvular Interstitial Cells' Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway.Journal of cardiovascular development and disease · 2023Article
- Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.