ArticleeLife2017
Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos.Development (Cambridge, England) · 2026Article
- The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in earlybioRxiv : the preprint server for biology · 2025Article
- No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo.Current topics in developmental biology · 2025Review
- Greatwall-Endos-PP2A/B55Open biology · 2024Article
- Two distinct waves of transcriptome and translatome changes drive Drosophila germline stem cell differentiation.The EMBO journal · 2024Article
- Finishing the egg.Genetics · 2024Article
- Review
- Review
- Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression.G3 (Bethesda, Md.) · 2022Article
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- Calcineurin-dependent Protein Phosphorylation Changes During Egg Activation inMolecular & cellular proteomics : MCP · 2019Article
- Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.Cell communication and signaling : CCS · 2018Article
- Activating embryonic development in Drosophila.Seminars in cell & developmental biology · 2018Review
- Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis inG3 (Bethesda, Md.) · 2018Article
- Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Post-translational regulation of the maternal-to-zygotic transition.Cellular and molecular life sciences : CMLS · 2018Review
- Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.Journal of developmental biology · 2018Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The oocyte-to-embryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under precise developmental control. Despite presence of the catalytic PNG subunit and the PLU and GNU activating subunits in the mature oocyte, GNU is phosphorylated at Cyclin B/CDK1sites and unable to bind PNG and PLU. In vitro phosphorylation of GNU by CyclinB/CDK1 blocks activation of PNG. Meiotic completion promotes GNU dephosphorylation and PNG kinase activation to regulate translation. The critical regulatory effect of phosphorylation is shown by replacement in the oocyte with a phosphorylation-resistant form of GNU, which promotes PNG-GNU complex formation, elevation of Cyclin B, and meiotic defects consistent with premature PNG activation. After PNG activation GNU is destabilized, thus inactivating PNG. This short-lived burst in kinase activity links development with maternal mRNA translation and ensures irreversibility of the oocyte-to-embryo transition.
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