Evidence map›Paper›PMID 28555497›Full record

ArticleFuture microbiology2017

Ldt

Rohini Mattoo, Evan P Lloyd, Amit Kaushik, Pankaj Kumar, Julie L Brunelle, Craig A Townsend, Gyanu Lamichhane

Open access · hybridAbstract read
In one paragraph

Article in Future microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  2. Oral β-lactam combinations are effectiveMicrobiology spectrum · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Select β-Lactam Combinations Exhibit Synergy againstAntimicrobial agents and chemotherapy · 2019
    Article
  9. Review
  10. Article
  11. Frontiers in microbiology · 2018
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rohini MattooDepartment of Medicine, Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD 21231, USA.
Evan P LloydDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
Amit KaushikDepartment of Medicine, Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD 21231, USA.
Pankaj KumarDepartment of Medicine, Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD 21231, USA.
Julie L BrunelleHoward Hughes Medical Institute, Department of Molecular Biology & Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
Gyanu LamichhaneDepartment of Medicine, Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD 21231, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USHoward Hughes Medical Institute · US

Funding

Biosynthesis of Beta Lactam AntibioticsR01AI121072 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2016 to 2025
$4.9M
New Drug for Treatment of Chronic Bacterial InfectionDP2OD008459 · OD · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2011 to 2013
$2.6M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI121072NIH HHS DP2 OD008459
6 · The paper itself

Abstract

aimMycobacterium avium infections, especially in immune-compromised individuals, present a significant challenge as therapeutic options are limited. In this study, we investigated if M. avium genome encodes nonclassical transpeptidases and if newer carbapenems are effective against this mycobacteria. MATERIALS &

methodsBiochemical and microbiological approaches were used to identify and characterize a nonclassical transpeptidase, namely L,D-transpeptidase, in M. avium. RESULTS &

conclusionWe describe the biochemical and physiological attributes of a L,D-transpeptidase in M. avium, Ldt

Indexed as

Anti-Bacterial Agentsbeta-LactamsCarbapenemsCrystallography, X-RayDrug Resistance, Multiple, BacterialGenome, BacterialMycobacterium avium ComplexPeptidyl TransferasesSequence Analysis, DNAAnti-Bacterial Agentsbeta-LactamsCarbapenemsPeptidyl TransferasestebipenemcarbapenemL,D-transpeptidasemycobacteriaMycobacterium aviumpeptidoglycantebipenem

Identifiers

PMID28555497
PMCPMC5619143
OpenAlexW2617527338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.