Evidence map›Paper›PMID 28555406›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2018

Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach.

Mohamed Abdulkadir, Douglas Londono, Derek Gordon, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Lonneke Elzerman, Carolin Fremer, Odette Fründt and 39 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Investigation of gene-environment interactions in relation to tic severity.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors at 20 institutions in 7 countries.

Mohamed AbdulkadirDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. abdulkadir@dls.rutgers.edu.ORCID http://orcid.org/0000-0002-6080-257X
Douglas LondonoDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Derek GordonDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Thomas V FernandezDepartment of Psychiatry, Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Lawrence W BrownChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Keun-Ah CheonYonsei University College of Medicine, Yonsei Yoo & Kim Mental Health Clinic, Seoul, South Korea.
Barbara J CoffeyDivision of Tics, OCD and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lonneke ElzermanYulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands.
Carolin FremerMedizinische Hochschule Hannover Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Hannover, Germany.
Odette FründtUniversity Hospital Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Blanca Garcia-DelgarDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.
Donald L GilbertCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Dorothy E GriceDivision of Tics, OCD and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tammy HedderlyEvelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
Isobel HeymanGreat Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
Hyun Ju HongHallym University Sacred Heart Hospital, Anyang, South Korea.
Chaim HuyserDe Bascule, Amsterdam, The Netherlands.
Laura Ibanez-GomezDivision of Tics, OCD and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ewgeni JakubovskiMedizinische Hochschule Hannover Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Hannover, Germany.
Young Key KimYonsei Bom Clinic, Seoul, South Korea.
Young Shin KimDepartment of Psychiatry, University of California, San Francisco, USA.
Yun-Joo KohKorea Institute for Children's Social Development, Seoul, South Korea.
Sodahm KookKangbuk Samsung Hospital, Seoul, South Korea.
Samuel KupermanUniversity of Iowa Carver College of Medicine, Iowa City, IA, USA.
Bennett LeventhalDepartment of Psychiatry, University of California, San Francisco, USA.
Andrea G LudolphDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.
Marcos Madruga-GarridoSección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Athanasios MarasYulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The Netherlands.
Pablo MirUnidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Astrid MorerDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.
Kirsten Müller-VahlMedizinische Hochschule Hannover Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Hannover, Germany.
Alexander MünchauInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Tara L MurphyGreat Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UK.
Kerstin J PlessenChild and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Veit RoessnerDepartment of Child and Adolescent Psychiatry, TU Dresden, Dresden, Germany.
Eun-Young ShinYonsei University College of Medicine, Yonsei Yoo & Kim Mental Health Clinic, Seoul, South Korea.
Dong-Ho SongYonsei University College of Medicine, Yonsei Yoo & Kim Mental Health Clinic, Seoul, South Korea.
Jungeun SongNational Health Insurance Service Ilsan Hospital, Goyang-Si, South Korea.
Jennifer TübingInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Els van den BanYouth Division, Altrecht, Institute for Mental Health, Utrecht, The Netherlands.
Frank VisscherDepartment of Neurology, Admiraal De Ruyter Ziekenhuis, Goes, The Netherlands.
Sina WandererDepartment of Child and Adolescent Psychiatry, TU Dresden, Dresden, Germany.
Martin WoodsEvelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.
Samuel H ZinnerDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Robert A KingDepartment of Psychiatry, Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Jay A TischfieldDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Gary A HeimanDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Andrea DietrichDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Rutgers, The State University of New Jersey · USMedizinische Hochschule Hannover · DEUniversity of California, San Francisco · USYonsei University · KRGreat Ormond Street Hospital · GBInstituto de Biomedicina de Sevilla · ESKings Health Partners · GBNathan Kline Institute for Psychiatric Research · USTechnische Universität Dresden · DEUniversity Medical Center Groningen · NLUniversity of Lübeck · DEYale University · USYulius · NLAdmiraal De Ruyter Ziekenhuis · NLAltrecht GGZ · NLCentro de Investigación Biomédica en Red de Salud Mental · ESChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USDe Bascule · NLHallym University Sacred Heart Hospital · KR

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
1/7 Collaborative Genomic Studies of Tourette Disorder.R01MH115958 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HEIMAN, GARY A., TISCHFIELD, JAY ARNOLD · 2018 to 2023
$6.8M
Research Training for Medical Students & Physician-Scientists in Child PsychiatryR25MH077823 · NIMH · YALE UNIVERSITY · PI ANDRES S MARTIN · 2006 to 2026
$4.0M
2/8-Collaborative genomic studies of Tourette DisorderR01MH092289 · NIMH · YALE UNIVERSITY · PI STATE, MATTHEW W. · 2011 to 2013
$898k
4/7-Collaborative genomic studies of Tourette DisorderR01MH115962 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI GILBERT, DONALD L · 2018 to 2022
$810k
Genomic Investigations of Tourette's DisorderK08MH099424 · NIMH · YALE UNIVERSITY · PI FERNANDEZ, THOMAS V · 2012 to 2015
$718k
7/7-Collaborative genomic studies of Tourette DisorderR01MH115959 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI COFFEY, BARBARA JANE · 2018 to 2022
$690k
1/8-Collaborative genomic studies of Tourette DisorderR01MH092293 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HEIMAN, GARY A., TISCHFIELD, JAY ARNOLD · 2011 to 2013
$510k
Collaborative Genomic Studies of Tourette Disorder SupplementR01MH115961 · NIMH · UNIVERSITY OF IOWA · PI KUPERMAN, SAMUEL · 2018 to 2022
$475k
6/7-Collaborative genomic studies of Tourette Disorder.R01MH115993 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI ZINNER, SAMUEL HAMILTON · 2018 to 2022
$369k
8/8-Collaborative Genomic Studies of Tourette DisorderR01MH092292 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COFFEY, BARBARA JANE, LEVENTHAL, BENNETT L. · 2011 to 2013
$280k
3/8-Collaborative Genomic Studies of Tourette DisorderR01MH092290 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BROWN, LAWRENCE W · 2011 to 2013
$248k
Consejería de Economía, Innovación, Ciencia y Empresa de la Junta de Andalucía CVI-02526, CTS-7685Consejería de Salud y Bienestar Social de la Junta de Andalucía PI-0741/2010, PI-0437-2012, PI-0471-2013Deutsche Forschungsgemeinschaft MU 1692/3-1, MU 1692/4-1, project C5 of the SFB 936Instituto de Salud Carlos III PI10/01674, PI13/01461NIMH NIH HHS K08 MH099424NIMH NIH HHS R01 MH092289NIMH NIH HHS R01 MH092290NIMH NIH HHS R01MH092290, R01MH092291, R01MH092292, R01MH092293, R01MH092513, R01MH092516, R01MH092520, R01MH092289, K08MH099424NIMH NIH HHS R01 MH092291NIMH NIH HHS R01 MH092292NIMH NIH HHS R01 MH092293NIMH NIH HHS R01 MH092513NIMH NIH HHS R01 MH092516NIMH NIH HHS R01 MH092520NIMH NIH HHS R01 MH115958NIMH NIH HHS R01 MH115959NIMH NIH HHS R01 MH115961NIMH NIH HHS R01 MH115962NIMH NIH HHS R01 MH115993NIMH NIH HHS R25 MH077823NIMH NIH HHS U24 MH068457Pharmaceutical Research and Manufacturers of America Foundation Informatics Starter Grant
6 · The paper itself

Abstract

Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case-control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive-compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were tagging SNPs from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top SNPs from TS GWAS; and 13 top SNPs from attention-deficit/hyperactivity disorder, OCD, or ASD GWAS. None of the SNPs or genes reached significance after adjustment for multiple testing. We observed nominal significance for the candidate SNPs rs3744161 (TBCD) and rs4565946 (TPH2) and for five tagging SNPs; none of these showed significance in the independent cohort. Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM). We found no convincing support for previously implicated genetic polymorphisms. Targeted re-sequencing should fully appreciate the relevance of candidate genes.

Indexed as

Family HealthAdolescentAdultChildChild, PreschoolFemaleGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMicrotubule-Associated ProteinsMiddle AgedPolymorphism, Single NucleotideSeverity of Illness IndexTic DisordersMicrotubule-Associated ProteinsTBCD protein, humanTPH2 protein, humanTryptophan HydroxylaseAttention-deficit/hyperactivity disorderCandidate gene studyObsessive–compulsive disorderTourette syndromeTransmission Disequilibrium Test

Identifiers

PMID28555406
PMCPMC5708161
OpenAlexW2620191024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.