Evidence map›Paper›PMID 28555371›Full record

ArticleNeuroinformatics2017

Hierarchical High-Order Functional Connectivity Networks and Selective Feature Fusion for MCI Classification.

Xiaobo Chen, Han Zhang, Seong-Whan Lee, Dinggang Shen, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in Neuroinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  11. Review
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  14. Inter-subject Similarity Guided Brain Network Modeling for MCI Diagnosis.Machine learning in medical imaging. MLMI (Workshop) · 2017
    Article
  15. Constructing Multi-frequency High-Order Functional Connectivity Network for Diagnosis of Mild Cognitive Impairment.Connectomics in neuroimaging : First International Workshop, CNI 2017, held in conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, proceedings. CNI (Workshop) (1st : 2017 : Quebec, Quebec) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaobo ChenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0001-9940-1637
Han ZhangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA.
Seong-Whan LeeDepartment of Brain and Cognitive Engineering, Korea University, Seoul, 02841, Republic of Korea.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA. dgshen@med.unc.edu.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Analyzing Large-Scale Neuroimaging Data in Alzheimer's DiseaseRF1AG053867 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2016
$2.5M
Imaging Genomics Based Brain Disease PredictionR01AG049371 · NIA · UNIVERSITY OF TEXAS ARLINGTON · PI HUANG, HENG · 2015 to 2019
$2.0M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Diagnosis of Alzheimer's Disease Using Dynamic High-Order Brain NetworksR01EB022880 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIA NIH HHS R01 AG049371NIA NIH HHS RF1 AG053867NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB022880
6 · The paper itself

Abstract

Conventional Functional connectivity (FC) analysis focuses on characterizing the correlation between two brain regions, whereas the high-order FC can model the correlation between two brain region pairs. To reduce the number of brain region pairs, clustering is applied to group all the brain region pairs into a small number of clusters. Then, a high-order FC network can be constructed based on the clustering result. By varying the number of clusters, multiple high-order FC networks can be generated and the one with the best overall performance can be finally selected. However, the important information contained in other networks may be simply discarded. To address this issue, in this paper, we propose to make full use of the information contained in all high-order FC networks. First, an agglomerative hierarchical clustering technique is applied such that the clustering result in one layer always depends on the previous layer, thus making the high-order FC networks in the two consecutive layers highly correlated. As a result, the features extracted from high-order FC network in each layer can be decomposed into two parts (blocks), i.e., one is redundant while the other might be informative or complementary, with respect to its previous layer. Then, a selective feature fusion method, which combines sequential forward selection and sparse regression, is developed to select a feature set from those informative feature blocks for classification. Experimental results confirm that our novel method outperforms the best single high-order FC network in diagnosis of mild cognitive impairment (MCI) subjects.

Indexed as

Brain MappingBrainCase-Control StudiesCluster AnalysisCognitive DysfunctionFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, NeurologicalNeural PathwaysOxygenOxygenBrain disease diagnosisFunctional connectivityHierarchical clusteringHigh-order network

Identifiers

PMID28555371
PMCPMC5541911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.