Evidence map›Paper›PMID 28555306›Full record

ArticlePathology oncology research : POR2018

Prognostic Value of Perineural Invasion in Resected Gastric Cancer Patients According to Lauren Histotype.

Lorenzo De Franco, Daniele Marrelli, Costantino Voglino, Carla Vindigni, Francesco Ferrara, Giulio Di Mare, Livio Iudici, Mario Marini, Franco Roviello

Abstract read
PubMed Publisher
In one paragraph

Article in Pathology oncology research : POR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  18. Optimal management of resected gastric cancer.Cancer management and research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lorenzo De FrancoDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
Daniele MarrelliDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy. marrelli@unisi.it.
Costantino VoglinoDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
Carla VindigniDepartment of Medicine, Surgery and Neurosciences, Unit of Pathology, University of Siena, 53100, Siena, Italy.
Francesco FerraraDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
Giulio Di MareDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
Livio IudiciDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
Mario MariniDepartment of Oncology, Unit of gastroenterology and endoscopy, "Santa Maria alle Scotte" Hospital, 53100, Siena, Italy.
Franco RovielloDepartment of Medicine, Surgery and Neurosciences, Unit of Surgical Oncology, University of Siena, 53100, Siena, Italy.
University of Siena · ITOspedale Santa Maria alle Scotte · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to investigate perineural invasion (PNI) as a prognostic factor in gastric cancer patients. 455 patients submitted to extended (D2 or more) lymphadenectomy (median number of 39 retrieved lymph nodes, range: 15-140) between 1995 and 2012 were retrospectively studied. Patients were categorized in two groups according to the PNI status, and PNI positivity was assessed in presence of cancer cells in the perinerium or the neural fascicles using hematoxylin and eosin staining. Median follow-up for surviving patients was 80.3 months. Survival analysis was performed by univariate and multivariate analysis, using a Cox proportional hazards model. 162 patients (33.9%) had positive PNI; this was strongly associated with advanced stages of disease, residual tumor, lymphovascular invasion, Lauren diffuse-mixed histotype and tumor size. Five-year cancer-related survival was 65,7% and 20,6% in PNI negative vs. positive groups, respectively (p < 0.001). The prognostic impact of PNI at univariate analysis was particularly evident in patients submitted to R0 surgery, early as well as advanced stage, advanced nodal stage and T status. At multivariate analysis, PNI did not result statistically significant in the overall series, but emerged as an independent prognostic factor in the group of patients with Lauren intestinal histotype (p = 0.005, hazard ratio: 1.99, 95% confidence interval 1.24-3.19). PNI is related to advanced stage and poor long-term survival in gastric cancer, and may serve as an adjunctive prognostic factor in the intestinal histotype.

Indexed as

AdenocarcinomaAgedCohort StudiesDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPeripheral NervesPrognosisProportional Hazards ModelsRetrospective StudiesStomach NeoplasmsExtended lymphadenectomyGastric cancerLauren histotypePerineural invasionPrognostic factors

Identifiers

PMID28555306
OpenAlexW2617439368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.