Evidence map›Paper›PMID 28555274›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017

Survival analysis of 287 oropharyngeal squamous cell carcinoma patients in a single institution: a retrospective comparison of two consecutive time intervals with surgical and conservative treatment approaches.

Adrian Münscher, Lara Bussmann, Susanne Sehner, Simon Knaack, Alexandra Gliese, Silke Tribius, Till Clauditz, Balazs B Lörincz

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adrian MünscherDepartment of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Lara BussmannDepartment of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Susanne SehnerDepartment of Medical Biometry and Epidemiology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Simon KnaackDepartment of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Alexandra GlieseDepartment of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Silke TribiusHermann-Holthusen Institute for Radiotherapy of the Asklepios St. Georg Hospital affiliated to the Semmelweis University Budapest, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Till ClauditzDepartment of Pathology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Balazs B LörinczDepartment of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. b.loerincz@asklepios.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated. Main outcome measures were overall survival (OS) and recurrence-free survival (RFS). Between 2002 and 2007, early-stage OPSCC showed a 5-year OS of 75% compared to that of 86% between 2008 and 2013. Locally advanced OPSCC showed a 5-year OS of 66% between 2002 and 2007 compared to that of 74% between 2008 and 2013. RFS in early-stage OPSCC was 48% between 2002 and 2007 in contrast to that of 77% between 2008 and 2013. With locally advanced OPSCC, RFS was 55% between 2002 and 2007 compared to that of 56% between 2008 and 2013. These differences were statistically not significant. The OS and RFS remained generally unchanged over the analysed time period. There was no significant difference in the outcomes with regards to HPV status and to their treatment modality.

Indexed as

Carcinoma, Squamous CellChemoradiotherapy, AdjuvantConservative TreatmentNeoplasm Recurrence, LocalOropharyngeal NeoplasmsOtorhinolaryngologic Surgical ProceduresAdultAgedFemaleGermanyHumansMaleMiddle AgedNeoplasm StagingOrgan PreservationOutcome and Process Assessment, Health CareHuman papilloma virusOropharyngeal cancerOutcomesPrimary chemoradiotherapyPrimary surgery

Identifiers

PMID28555274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.