ArticleNature biomedical engineering2017
Multimodal laser-based angioscopy for structural, chemical and biological imaging of atherosclerosis.
Article in Nature biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis.Stroke and vascular neurology · 2022Pooled it
- Perspective review on applications of optics in cerebral endovascular neurosurgery.Journal of biomedical optics · 2019Pooled it
- From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease.Light, science & applications · 2026Review
- Towards clinical translation of nanomedicines: Formulation scale-up and model systems.Advanced drug delivery reviews · 2026Review
- Feasibility of Using Angioscopy to Visualize the Internal Vessel Wall of the Internal Carotid Artery.Clinical neuroradiology · 2026Article
- Near-Infrared-II Fluorescence Imaging of Tumors with Organic Small-Molecule Fluorophores.Sensors (Basel, Switzerland) · 2025Review
- Development of a multiparameter phantom system for multispectral imaging.Biomedical optics express · 2025Article
- Visualization of Plaque Erosion With Laser Angioscopy.JACC. Case reports · 2025Article
- Camera-on-tip endoscope forBiomedical optics express · 2025Article
- Strategies for enhanced gene delivery to the central nervous system.Nanoscale advances · 2024Review
- Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs.Scientific reports · 2023Article
- Molecular Imaging for Early-Stage Disease Diagnosis.Advances in experimental medicine and biology · 2023Article
- Highly sensitive HActa pharmaceutica Sinica. B · 2023Article
- Unifying theory of carotid plaque disruption based on structural phenotypes and forces expressed at the lumen/wall interface.Stroke and vascular neurology · 2022Article
- Quantification of clot spatial heterogeneity and its impact on thrombectomy.Journal of neurointerventional surgery · 2022Article
- Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease.Stroke and vascular neurology · 2022Article
- Article
- Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation.IEEE transactions on bio-medical engineering · 2021Article
- Deep Neural Network-Aided Histopathological Analysis of Myocardial Injury.Frontiers in cardiovascular medicine · 2021Article
- Applications of a Novel Microangioscope for Neuroendovascular Intervention.AJNR. American journal of neuroradiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
The complex nature of atherosclerosis demands high-resolution approaches to identify subtle thrombogenic lesions and define the risk of plaque rupture. Here, we report the proof-of-concept use of a multimodal scanning fiber endoscope (SFE) consisting of a single optical fiber scanned by a piezoelectric drive that illuminates tissue with red, blue, and green laser beams, and digitally reconstructs images at 30 Hz with high resolution and large fields-of-view. By combining laser-induced reflectance and fluorescence emission of intrinsic fluorescent constituents in arterial tissues, the SFE allowed us to co-generate endoscopic videos with a label-free biochemical map to derive a morphological and spectral classifier capable of discriminating early, intermediate, advanced, and complicated atherosclerotic plaques. We demonstrate the capability of scanning fiber angioscopy for the molecular imaging of vulnerable atherosclerosis by targeting proteolytic activity with a fluorescent probe activated by matrix metalloproteinases. We also show that the SFE generates high-quality spectral images
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.