Evidence map›Paper›PMID 28555065›Full record

ArticleCancers2017

A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo.

Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H Sherman, Colin Young, Michael Keidar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 134 citations in OpenAlex.

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  17. Effect of cold atmospheric plasma on changing of biomolecular structures involved in apoptosis pathways of melanoma cancer.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhitong ChenDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA. zhitongchen@gwu.edu.
Hayk SimonyanDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC 20052, USA. xiaoqian@gwmail.gwu.edu.
Xiaoqian ChengDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA. egjika@gwu.edu.
Eda GjikaDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA. lilin@email.gwu.edu.
Li LinDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA. hayksimonyan@email.gwu.edu.
Jerome CanadyJerome Canady Research Institute for Advanced Biological and Technological Sciences, US Medical innovation LLC, Takoma Park, MD 20912, USA. drjcanady@canadysurgicalgroup.com.
Jonathan H ShermanDepartment of Neurosurgery, The George Washington University, Washington, DC 20052, USA. jsherman@mfa.gwu.edu.
Colin YoungDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC 20052, USA. colinyoung@gwu.edu.
Michael KeidarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA. colinyoung@gwu.edu.
George Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) treatment is a rapidly expanding and emerging technology for cancer treatment. Direct CAP jet irradiation is limited to the skin and it can also be invoked as a supplement therapy during surgery as it only causes cell death in the upper three to five cell layers. However, the current cannulas from which the plasma emanates are too large for intracranial applications. To enhance efficiency and expand the applicability of the CAP method for brain tumors and reduce the gas flow rate and size of the plasma jet, a novel micro-sized CAP device (µCAP) was developed and employed to target glioblastoma tumors in the murine brain. Various plasma diagnostic techniques were applied to evaluate the physics of helium µCAP such as electron density, discharge voltage, and optical emission spectroscopy (OES). The direct and indirect effects of µCAP on glioblastoma (U87MG-RedFluc) cancer cells were investigated in vitro

Indexed as

cancer therapyglioblastomamicro-sized plasma devicereactive nitrogen speciesreactive oxygen species

Identifiers

PMID28555065
PMCPMC5483880
OpenAlexW2618863422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.