ArticleInternational journal of environmental research and public health2017
The Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China).
Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Silent Threat Evolution: Critically Important Carbapenem and Colistin Resistance Genes in the Natural Aquatic Environment.Antibiotics (Basel, Switzerland) · 2026Review
- One Health at Risk: Plasmid-Mediated Spread ofAntibiotics (Basel, Switzerland) · 2025Review
- Plasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil.Antibiotics (Basel, Switzerland) · 2022Review
- Removal of Extended-Spectrum Beta-Lactamase-ProducingInternational journal of environmental research and public health · 2022Article
- The variants of polymyxin susceptibility in different species of genusFrontiers in microbiology · 2022Article
- Fecal indicators and antibiotic resistance genes exhibit diurnal trends in the Chattahoochee River: Implications for water quality monitoring.Frontiers in microbiology · 2022Article
- Characteristics of the plasmid-mediated colistin-resistance geneFrontiers in microbiology · 2022Article
- Diversity and abundance of antibiotic resistance genes and their relationship with nutrients and land use of the inflow rivers of Taihu Lake.Frontiers in microbiology · 2022Article
- Detection of mcr-1-positive Escherichia coli in slaughterhouse wastewater collected from Dawen river.Veterinary medicine and science · 2021Article
- A Large Spatial Survey of Colistin-Resistant GeneMicroorganisms · 2021Article
- The Role of FecalDisease markers · 2021Article
- New Estimation of Antibiotic Resistance Genes in Sediment Along the Haihe River and Bohai Bay in China: A Comparison Between Single and Successive DNA Extraction Methods.Frontiers in microbiology · 2021Article
- The global distribution and spread of the mobilized colistin resistance gene mcr-1.Nature communications · 2018Article
- Detection ofAntimicrobial agents and chemotherapy · 2018Article
- Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Review
- The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.Frontiers in microbiology · 2018Article
- Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin.F1000Research · 2017Review
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ecosystems are recognized as reservoirs for antibiotic resistant bacteria (ARB) and ARGs. In this study, a qPCR assay was developed to monitor and quantify the mcr-1 gene in the Haihe River, China. The results showed that all 18 samples collected from different locations over 6 months along the Haihe River were positive for the mcr-1 gene, and the highest level of mcr-1 reached 3.81 × 105 gene copies (GC) per liter of water. This is the first study to quantify mcr-1 in a natural water system by qPCR. Our findings highlight the potential for this antibiotic resistance determinant to spread extensively, suggesting a significant health and ecological impact.
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