ArticleJournal of neurology, neurosurgery, and psychiatry2018
Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke.
Article in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Patterns of Infarction on MRI in Patients With Acute Ischemic Stroke and Cardio-Embolism: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial.BMC medicine · 2026Trial
- Atrial Fibrillation, Brain Structure and Cognitive Function: A Mediation Analysis.Korean circulation journal · 2026Article
- Linking atrial fibrillation to cerebral small vessel disease: a cross-sectional study with predictive analytics.Frontiers in cardiovascular medicine · 2026Article
- Subtle signs of atrial cardiomyopathy and left ventricular diastolic dysfunction are associated with reduced cognitive function: results from the Hamburg City Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Relationship between elevated homocysteine levels and the degree of white matter lesions in stroke patients.Medicine · 2025Observational
- Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study.Scientific reports · 2025Article
- Neuroglial Biomarkers for Risk Assessment of Ischemic Stroke and Other Cardiovascular Events in Patients With Atrial Fibrillation Not Receiving Oral Anticoagulation.Journal of the American Heart Association · 2025Article
- Cerebral small vessel disease was associated with the prognosis in ischemic stroke with atrial fibrillation.CNS neuroscience & therapeutics · 2024Article
- Association Between the Timing of Atrial Fibrillation Detection and Functional Outcome Following Mechanical Thrombectomy.Journal of the American Heart Association · 2024Article
- Vagus nerve size determined via ultrasonography is associated with white matter lesions in patients with vascular risk factors.Journal of ultrasound · 2024Article
- Impact of Systolic Blood Viscosity on Deep White Matter Hyperintensities in Patients With Acute Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Imaging features for the identification of atrial fibrillation in cryptogenic stroke patients.Journal of neurology · 2024Observational
- Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management.Heart rhythm O2 · 2024Article
- Apolipoprotein E ɛ2 Is Associated with the White Matter Hyperintensity Multispot Pattern in Spontaneous Intracerebral Hemorrhage.Translational stroke research · 2024Article
- Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis.Journal of the American Heart Association · 2023Article
- Contribution of Conventional Cardiovascular Risk Factors to Brain White Matter Hyperintensities.Journal of the American Heart Association · 2023Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Serum Neurofilament Light Chain in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2022Observational
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveHigh white matter hyperintensity (WMH) burden is commonly found on brain MRI among patients with atrial fibrillation (AF). However, whether the link between AF and WMH extends beyond a common vascular risk factor profile is uncertain. We sought to determine whether AF relates to a distinct WMH lesion pattern which may suggest specific underlying pathophysiological relationships.
methodsWe retrospectively analysed a cohort of consecutive patients presenting with embolic stroke at an academic hospital and tertiary referral centre between March 2010 and March 2014. In total, 234 patients (53% female, 74% anterior circulation infarction) fulfilled the inclusion criteria and were included in the analyses. WMH lesion distribution was classified according to previously defined categories. Multivariable logistic regression analysis was performed to determine variables associated with AF within 90 days of index hospital discharge.
resultsAmong included patients, 114 had AF (49%). After adjustment for the CHA
conclusionsAF is associated with specific WMH lesion pattern among patients with embolic stroke aetiology. This suggests that the link between AF and brain injury extends beyond thromboembolic complications to include a cardiovasculopathy that affects the brain and can be detected and characterised by WMH.
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