Evidence map›Paper›PMID 28554945›Full record

ReviewHaematologica2017

Genetic background and evolution of relapses in aggressive B-cell lymphomas.

Darius Juskevicius, Stephan Dirnhofer, Alexandar Tzankov

Abstract readReview
In one paragraph

Review in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Drug Resistance in Non-Hodgkin Lymphomas.International journal of molecular sciences · 2020
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Darius JuskeviciusInstitute of Pathology & Medical Genetics, University of Basel and University Hospital Basel, Switzerland.
Stephan DirnhoferInstitute of Pathology & Medical Genetics, University of Basel and University Hospital Basel, Switzerland.
Alexandar TzankovInstitute of Pathology & Medical Genetics, University of Basel and University Hospital Basel, Switzerland alexandar.tzankov@usb.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapses of aggressive B-cell lymphomas pose a higher risk to affected patients because of potential treatment resistance and usually rapid tumor growth. Recent advances, such as targeting Bruton tyrosine kinase, have provided promising results in small numbers of cases, but treatment for the majority of patients remains challenging and outcomes are generally poor. A number of recent studies have utilized state-of-the-art genomic technologies in an attempt to better understand tumor genome evolution during relapse and to identify relapse-specific genetic alterations. It has been found that in some settings (e.g. diffuse large B-cell lymphomas in immunocompromised patients, secondary diffuse large B-cell lymphomas as Richter transformations) a significant part of the recurrences are

Indexed as

Genetic BackgroundGenetic Predisposition to DiseaseAnimalsClonal EvolutionDisease ProgressionGenetic Association StudiesGenetic VariationHumansImmunomodulationLymphoma, B-CellRecurrence

Identifiers

PMID28554945
PMCPMC5566014

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.