Evidence map›Paper›PMID 28554926›Full record

SynthesisBMJ open2017

Long-term antibiotics for prevention of recurrent urinary tract infection in older adults: systematic review and meta-analysis of randomised trials.

Haroon Ahmed, Freya Davies, Nick Francis, Daniel Farewell, Christoper Butler, Shantini Paranjothy

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

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  20. Antibiotic prophylaxis for urinary tract infection.Canadian family physician Medecin de famille canadien · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Haroon AhmedDivision of Population Medicine, Cardiff University School of Medicine, Cardiff, UK.
Freya DaviesDivision of Population Medicine, Cardiff University School of Medicine, Cardiff, UK.
Nick FrancisDivision of Population Medicine, Cardiff University School of Medicine, Cardiff, UK.
Daniel FarewellDivision of Population Medicine, Cardiff University School of Medicine, Cardiff, UK.
Christoper ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Shantini ParanjothyDivision of Population Medicine, Cardiff University School of Medicine, Cardiff, UK.
Cardiff University · GBUniversity of Oxford · GB

Funding

HCRW_ NIHR-FS-2014Medical Research Council G0902108
6 · The paper itself

Abstract

objectiveTo address clinical uncertainties about the effectiveness and safety of long-term antibiotic therapy for preventing recurrent urinary tract infections (UTIs) in older adults.

designSystematic review andmeta-analysis of randomised trials.

methodWe searched Medline, Embase, The

resultsWe did not identify any studies that included older men. Three randomised controlled trials compared long-term antibiotics with vaginal oestrogens (n=150), oral lactobacilli (n=238) and D-mannose powder (n=94) in postmenopausal women. Long-term antibiotics reduced the risk of UTI recurrence by 24% (three trials, n=482; pooled risk ratio (RR) 0.76; 95% CI 0.61 to 0.95, number needed to treat=8.5). There was no statistically significant increase in risk of adverse events (mild adverse events: pooled RR 1.52; 95% CI 0.76 to 3.03; serious adverse events: pooled RR 0.90, 95% CI 0.31 to 2.66). One trial showed 90% of urinary and faecal

conclusionsFindings from three small trials with relatively short follow-up periods suggest long-term antibiotic therapy reduces the risk of recurrence in postmenopausal women with recurrent UTI. We did not identify any evidence to inform several clinically important scenarios including, benefits and harms in older men or frail care home residents, optimal duration of prophylaxis, recurrence rates once prophylaxis stops and effects on urinary antibiotic resistance.

Indexed as

AgedAnti-Bacterial AgentsDrug Resistance, MicrobialFemaleHumansPostmenopauseRandomized Controlled Trials as TopicSecondary PreventionTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsAnti-Bacterial AgentsTrimethoprim, Sulfamethoxazole Drug CombinationAntibiotic prophylaxisAntibiotic resistanceUrinary tract infections

Identifiers

PMID28554926
PMCPMC5729980
OpenAlexW2619788309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.