ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Development of Glutamatergic Proteins in Human Visual Cortex across the Lifespan.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Functional connectivity signatures of NMDAR dysfunction in schizophrenia-integrating findings from imaging genetics and pharmaco-fMRI.Translational psychiatry · 2023Trial
- The effective connectome over a century of human life.Communications biology · 2025Article
- Editorial: Paradigm shifts and innovations in cellular neuroscience.Frontiers in cellular neuroscience · 2025Article
- Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome.Journal of neurophysiology · 2024Article
- Anatomical and molecular development of the human primary visual cortex.Frontiers in cellular neuroscience · 2024Review
- GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway.Frontiers in molecular neuroscience · 2024Article
- Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period.Investigative ophthalmology & visual science · 2023Article
- Short-term homeostatic visual neuroplasticity in adolescents after two hours of monocular deprivation.IBRO neuroscience reports · 2023Article
- Perceptual Center-Surround Contrast Suppression in Adolescence.Investigative ophthalmology & visual science · 2023Article
- Calibrating Vision: Concepts and Questions.Vision research · 2022Review
- Corrigendum: A Practical Guide to SparseFrontiers in neuroscience · 2022Article
- A Practical Guide to SparseFrontiers in neuroscience · 2021Article
- Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure.Frontiers in neurology · 2021Article
- Dysregulation of excitatory neural firing replicates physiological and functional changes in aging visual cortex.PLoS computational biology · 2021Article
- TMT-Opsins differentially modulate medaka brain function in a context-dependent manner.PLoS biology · 2021Article
- A Primer on Constructing Plasticity Phenotypes to Classify Experience-Dependent Development of the Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Older Adults Exhibit Greater Visual Cortex Inhibition and Reduced Visual Cortex Plasticity Compared to Younger Adults.Frontiers in neuroscience · 2019Article
- Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.Translational psychiatry · 2018Article
- The development of human visual cortex and clinical implications.Eye and brain · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, human primary visual cortex (V1) has been thought to mature within the first few years of life, based on anatomical studies of synapse formation, and establishment of intracortical and intercortical connections. Human vision, however, develops well beyond the first few years. Previously, we found prolonged development of some GABAergic proteins in human V1 (Pinto et al., 2010). Yet as >80% of synapses in V1 are excitatory, it remains unanswered whether the majority of synapses regulating experience-dependent plasticity and receptive field properties develop late, like their inhibitory counterparts. To address this question, we used Western blotting of postmortem tissue from human V1 (12 female, 18 male) covering a range of ages. Then we quantified a set of postsynaptic glutamatergic proteins (PSD-95, GluA2, GluN1, GluN2A, GluN2B), calculated indices for functional pairs that are developmentally regulated (GluA2:GluN1; GluN2A:GluN2B), and determined interindividual variability. We found early loss of GluN1, prolonged development of PSD-95 and GluA2 into late childhood, protracted development of GluN2A until ∼40 years, and dramatic loss of GluN2A in aging. The GluA2:GluN1 index switched at ∼1 year, but the GluN2A:GluN2B index continued to shift until ∼40 year before changing back to GluN2B in aging. We also identified young childhood as a stage of heightened interindividual variability. The changes show that human V1 develops gradually through a series of five orchestrated stages, making it likely that V1 participates in visual development and plasticity across the lifespan.
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Registered trials
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