Evidence map›Paper›PMID 28554879›Full record

ArticleJMIR mHealth and uHealth2017

A Smartphone-Based Approach for Triage of Human Papillomavirus-Positive Sub-Saharan African Women: A Prospective Study.

Esther Urner, Martine Delavy, Rosa Catarino, Manuela Viviano, Ulrike Meyer-Hamme, Anne-Caroline Benski, Jeromine Jinoro, Josea Lea Heriniainasolo, Manuela Undurraga, Hugo De Vuyst and 3 more

Open access · goldAbstract read
In one paragraph

Article in JMIR mHealth and uHealth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Esther UrnerGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-2965-8039
Martine DelavyGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-8856-186X
Rosa CatarinoGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5317-7710
Manuela VivianoGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-7864-6731
Ulrike Meyer-HammeGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-7685-5812
Anne-Caroline BenskiGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-1184-882X
Jeromine JinoroLaboratory Division, Saint Damien Healthcare Centre, Ambanja, Madagascar.ORCID http://orcid.org/0000-0002-2199-701X
Josea Lea HeriniainasoloGynecology Division, Department of Gynecology and Obstetrics, Saint Damien Healthcare Centre, Ambanja, Madagascar.ORCID http://orcid.org/0000-0002-0987-1449
Manuela UndurragaGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-3345-8950
Hugo De VuystInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0002-5350-4072
Christophe CombescureResearch Center, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-2631-4780
Pierre VassilakosGeneva Foundation for Medical Education and Research, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-0926-4366
Patrick PetignatGynecology Division, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-6835-533X
University Hospital of Geneva · CHCentre international de recherche sur le cancer · FRFoundation for laboratory medicine · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundSub-Saharan African countries are marked by a high incidence of cervical cancer. Madagascar ranks 11th among the countries with the highest cervical cancer incidence worldwide.

objectiveThe aim of the study was to evaluate the performances of digital smartphone-based visual inspection with acetic acid (D-VIA) and Lugol's iodine (D-VILI) for diagnosing cervical precancer and cancer.

methodsHuman papillomavirus (HPV)-positive women recruited through a cervical screening campaign had D-VIA and D-VILI examinations with endocervical curettage (ECC) and cervical biopsy. Three images were captured for each woman (native, D-VIA, D-VILI) using a smartphone camera. The images were randomly coded and distributed on 2 online databases (Google Forms). The D-VIA form included native and D-VIA images, and the D-VILI form included native and D-VILI images. Pathological cases were defined as cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Physicians rated the images as non-pathological or pathological. Using the ECC and cervical biopsy results as references, the sensitivity and specificity of D-VIA and D-VILI examinations for each and all physicians were calculated.

resultsAltogether, 15 clinicians assessed 240 images. Sensitivity was higher for the D-VIA interpretations (94.1%; 95% CI 81.6-98.3) than for the D-VILI interpretations (78.8%; 95% CI 54.1-92.1; P=.009). In contrast, the specificity was higher for the D-VILI interpretations (56.4%; 95% CI 38.3-72.9) than for the D-VIA interpretations (50.4%; 95% CI 35.9-64.8; P=.005).

conclusionSmartphone-based image for triage of HPV-positive women is more accurate for detecting CIN2+ lesions with D-VIA than D-VILI, although with a small loss of specificity.

Indexed as

acetic acidcervical cancerHPVlugol’s iodinemobile phonesmartphonesquamous intraepithelial lesions of the cervix

Identifiers

PMID28554879
PMCPMC5468541
OpenAlexW2619831286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.