Evidence map›Paper›PMID 28554687›Full record

ReviewTrends in neurosciences2017

Endocannabinoid Signaling in the Control of Social Behavior.

Don Wei, Stephen Allsop, Kay Tye, Daniele Piomelli

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Endocannabinoid contributions to the perception of socially relevant, affective touch in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Anandamide Alters Glycolytic Activity inInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Psychotomimetic compensation versus sensitization.Pharmacology research & perspectives · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Don WeiDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA; School of Medicine, University of California, Irvine, CA, USA.
Stephen AllsopDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard Medical School, Harvard University, Boston, MA, USA.
Kay TyeDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Daniele PiomelliDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA; School of Medicine, University of California, Irvine, CA, USA. Electronic address: piomelli@uci.edu.
Massachusetts Institute of Technology · USUniversity of California, Irvine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Characterization of Anandamide Transport in BrainR01DA012413 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 1998 to 2016
$4.7M
NIDA NIH HHS R01 DA012413NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

Many mammalian species, including humans, exhibit social behavior and form complex social groups. Mechanistic studies in animal models have revealed important roles for the endocannabinoid signaling system, comprising G protein-coupled cannabinoid receptors and their endogenous lipid-derived agonists, in the control of neural processes that underpin social anxiety and social reward, two key aspects of social behavior. An emergent insight from these studies is that endocannabinoid signaling in specific circuits of the brain is context dependent and selectively recruited. These insights open new vistas on the neural basis of social behavior and social impairment.

Indexed as

Social BehaviorAnimalsCannabinoid Receptor ModulatorsEndocannabinoidsHumansReceptors, CannabinoidCannabinoid Receptor ModulatorsEndocannabinoidsReceptors, Cannabinoid2-arachidonoyl-sn-glycerolanandamideautism spectrum disorderschizophreniasocial anxietysocial reward

Identifiers

PMID28554687
PMCPMC5699224
OpenAlexW2618270881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.