ArticleNanomedicine : nanotechnology, biology, and medicine2018
Gradient nanocomposite hydrogels for interface tissue engineering.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Engineering Biomimetic 3D Microenvironments for Extracellular Vesicle Programming Toward Clinical Translation.International journal of molecular sciences · 2026Review
- Millimeter-Scale Dual-Opposing RNA-Gradient Hydrogel for Interfacial Gene Silencing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mapping the evolving landscape of conductive hydrogels in medicine: A bibliometric perspective.Regenerative therapy · 2026Article
- Extrusion of Heterogeneous Filament-like Structures: A New Paradigm in Fabricating Soft Mechanical Gradient with Long Span.Small science · 2025Article
- Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi-System Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Nanoclay-Composite Hydrogels for Bone Tissue Engineering.Gels (Basel, Switzerland) · 2024Review
- Outlook and opportunities for engineered environments of breast cancer dormancy.Science advances · 2024Review
- Bioinspired gradient scaffolds for osteochondral tissue engineering.Exploration (Beijing, China) · 2023Review
- Synthesis and Exfoliation of Calcium Organophosphonates for Tailoring Rheological Properties of Sodium Alginate Solutions: A Path toward Polysaccharide-Based Bioink.Biomacromolecules · 2023Article
- Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives.Bioactive materials · 2023Review
- Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments.Bioactive materials · 2023Review
- Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing.Bioactive materials · 2022Review
- Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Additively manufactured metallic biomaterials.Bioactive materials · 2022Review
- Carrageenan-Based Compounds as Wound Healing Materials.International journal of molecular sciences · 2022Review
- The Rheology and Printability of Cartilage Matrix-Only Biomaterials.Biomolecules · 2022Article
- Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration.International journal of molecular sciences · 2022Review
- Review
- Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics.Bioactive materials · 2022Review
- A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Two-dimensional (2D) nanomaterials are an emerging class of materials with unique physical and chemical properties due to their high surface area and disc-like shape. Recently, these 2D nanomaterials have been investigated for a range of biomedical applications including tissue engineering, therapeutic delivery and bioimaging, due to their ability to physically reinforce polymeric networks. Here, we present a facile fabrication of a gradient scaffold with two natural polymers (gelatin methacryloyl (GelMA) and methacrylated kappa carrageenan (MκCA)) reinforced with 2D nanosilicates to mimic the native tissue interface. The addition of nanosilicates results in shear-thinning characteristics of prepolymer solution and increases the mechanical stiffness of crosslinked gradient structure. A gradient in mechanical properties, microstructures and cell adhesion characteristics was obtained using a microengineered flow channel. The gradient structure can be used to understand cell-matrix interactions and to design gradient scaffolds for mimicking tissue interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.