Evidence map›Paper›PMID 28554507›Full record

ArticleLife sciences in space research2017

Track structure model of microscopic energy deposition by protons and heavy ions in segments of neuronal cell dendrites represented by cylinders or spheres.

Murat Alp, Francis A Cucinotta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences in space research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Murat AlpDepartment of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV, USA.
Francis A CucinottaDepartment of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV, USA. Electronic address: francis.cucinotta@unlv.edu.
University of Nevada, Las Vegas · US

Funding

(9) Biophysical Description of Age and Dose Dependent Changes to Dendritic Morphology that Impact Cognition following Radiation Cancer TherapyR01CA208526 · NCI · UNIVERSITY OF NEVADA LAS VEGAS · PI CUCINOTTA, FRANCIS A · 2016 to 2020
$2.4M
NCI NIH HHS R01 CA208526
6 · The paper itself

Abstract

Changes to cognition, including memory, following radiation exposure are a concern for cosmic ray exposures to astronauts and in Hadron therapy with proton and heavy ion beams. The purpose of the present work is to develop computational methods to evaluate microscopic energy deposition (ED) in volumes representative of neuron cell structures, including segments of dendrites and spines, using a stochastic track structure model. A challenge for biophysical models of neuronal damage is the large sizes (> 100µm) and variability in volumes of possible dendritic segments and pre-synaptic elements (spines and filopodia). We consider cylindrical and spherical microscopic volumes of varying geometric parameters and aspect ratios from 0.5 to 5 irradiated by protons, and

Indexed as

Heavy IonsModels, StructuralProtonsComputer SimulationCosmic RadiationDendritesHumansMonte Carlo MethodNeuronsRadiation DosageProtonsCentral nervous system effectsCognitive changesGalactic cosmic raysHadron therapyHeavy ionsNeuronal dendrites and spinesSpace radiationTrack structure models

Identifiers

PMID28554507
PMCPMC5495005
OpenAlexW2601047500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.