Evidence map›Paper›PMID 28554377›Full record

SynthesisJournal of psychosomatic research2017

Pharmacological treatment options for low Bone Mineral Density and secondary osteoporosis in Anorexia Nervosa: A systematic review of the literature.

Lauren Robinson, Victoria Aldridge, Emma M Clark, Madhusmita Misra, Nadia Micali

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychosomatic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Bone Fracture History in Women With First Episode or With Persistent Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Early-Onset Osteoporosis.Calcified tissue international · 2022
    Review
  9. Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022
    Review
  10. Review
  11. Article
  12. Bone Health in Childhood Chronic Disease.Endocrinology and metabolism clinics of North America · 2020
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lauren RobinsonInstitute of Child Health, University College London, Gower Street, London WC1E 6BT, UK; Dept. of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: Lauren.robinson.14@ucl.ac.uk.
Victoria AldridgeInstitute of Child Health, University College London, Gower Street, London WC1E 6BT, UK.
Emma M ClarkMusculoskeletal Research Unit, University of Bristol, Bristol, UK.
Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Nadia MicaliInstitute of Child Health, University College London, Gower Street, London WC1E 6BT, UK; Dept. of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
University College London · GBMassachusetts General Hospital · USUniversity of Bristol · GB

Funding

Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NICHD NIH HHS K24 HD071843
6 · The paper itself

Abstract

objectiveAlthough there are several evidence-based treatments available to increase Bone Mineral Density (BMD) and reduce fracture risk in aging men and women, there are still uncertainties regarding which treatments are efficacious in reducing lifetime fracture risk in women with Anorexia Nervosa (AN).

methodsMedline, PsychInfo, Embase and the Cochrane Database were searched for English Language Studies. Inclusion criteria were studies of females of any age with AN who received pharmacological treatment with the primary aim to increase BMD or reduce fracture risk. Data were extracted from each study regarding pharmacological treatment and dosage used, BMD and bone formation marker outcomes; and participant characteristics including age, Body Mass Index (BMI), duration of AN, and duration of amenorrhea.

results675 studies were reviewed, of which 19 fit the inclusion criteria and were included in the final review, investigating a total of 1119 participants; 10 of the 19 included studies were double-blind RCTs. The remaining studies consisted of prospective observational studies, a retrospective cohort study, a case-control study and five non-randomised control trials. Bisphosphonates were effective in increasing BMD in adult women with AN, while estrogen administered transdermally resulted in significant increases in BMD in mature adolescents with AN. Administration of oral contraceptives (OC) did not significantly increase BMD in randomised or controlled trials, however, lifetime OC use was associated with higher spinal BMD.

conclusionFuture research should clarify the safety of long-term bisphosphonate use in adult women with AN, and verify that transdermal estrogen replacement increases BMD in women with AN.

Indexed as

Anorexia NervosaBone DensityFemaleHumansOsteoporosisTreatment Outcome

Identifiers

PMID28554377
PMCPMC7050204
OpenAlexW2613452231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.