Evidence map›Paper›PMID 28554325›Full record

ReviewCurrent medicinal chemistry2018

Mycosporine-Like Amino Acids for Skin Photoprotection.

Karl P Lawrence, Paul F Long, Antony R Young

Abstract readReview
In one paragraph

Review in Current medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 151 citations in OpenAlex.

  1. Review
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  8. Microalgae: revolutionizing skin repair and enhancement.Biotechnology reports (Amsterdam, Netherlands) · 2025
    Review
  9. Review
  10. The role of mycosporine-like amino acids in skin care formulations: a patent review (2014-2024).Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  11. Article
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  17. Applications of mycosporine-like amino acids beyond photoprotection.Applied and environmental microbiology · 2023
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Karl P LawrenceSt. John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Paul F LongInstitute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Antony R YoungSt. John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
King's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive human exposure to solar ultraviolet radiation (UVR) continues to be a major public health concern, with skin cancer rates increasing year on year. The major protective measure is the use of synthetic UVR filters formulated into sunscreens, but there is a growing concern that some of these chemicals cause damage to delicate marine ecosystems. One alternative is the use of biocompatible mycosporine-like amino acids (MAA), which occur naturally in a wide range of marine species. Their role within nature is mainly thought to be photoprotective. However, their potential for human photoprotection is largely understudied.

objectiveTo review the role of MAA in nature and assess their potential as natural sunscreens for human skin photoprotection.

methodA literature review of all relevant papers was conducted.

conclusionMAA are natural photostable compounds that are thought to offer photoprotection to marine species. Initially thought of as protective based on their absorption properties in the solar UVR spectrum, it is clear that MAA are multifunctional photoprotective compounds acting as chemical and biological anti-oxidants. This suggests that MAA may offer a novel eco-friendly approach to human skin photoprotection. Most studies have been carried out in vitro and current data strongly suggest that MAA have potential for development as natural biocompatible sunscreens that protect against a diverse range of solar UVR induced adverse effects on human health.

Indexed as

Radiation ProtectionAmino AcidsAnimalsHumansSkinUltraviolet Rays1050-Da MAAAmino Acidsmechanismsmycosporine-like amino acidsnatural productsPhotoprotectionskinsolar radiation.

Identifiers

PMID28554325
PMCPMC6446518
OpenAlexW2618895543

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.