ArticleEnvironment international2017
Phthalates and thyroid function in preschool age children: Sex specific associations.
Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Frontiers in endocrinology · 2026Pooled it
- The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review.European journal of pediatrics · 2024Pooled it
- Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2019Pooled it
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Thyroid/parathyroid function and fluoride: role of mitochondrial DNA and SOD genetic variations.Journal of endocrinological investigation · 2026Article
- Developmental Exposure to Endocrine Disruptors and Persistent Pollutants Heightens Addiction Risk via Toxicological Mechanisms.Biomolecules & therapeutics · 2026Review
- Pregnancy exposure to individual phthalate concentrations and their mixtures in relation to pediatric serum antibody response.European journal of epidemiology · 2026Article
- Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction.Frontiers in behavioral neuroscience · 2026Review
- Gestational phthalate levels and biomarkers of aging in infants and children from New York City.Environmental research · 2025Article
- Article
- Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure.Current nutrition reports · 2025Review
- Relationship of urinary bisphenol A in childhood on thyroid hormone function in adolescents: a cohort study.PloS one · 2025Article
- Early childhood exposures to phthalates in association with attention-deficit/hyperactivity disorder behaviors in middle childhood and adolescence in the ReCHARGE study.International journal of hygiene and environmental health · 2024Article
- Implications of Prenatal Exposure to Endocrine-Disrupting Chemicals in Offspring Development: A Narrative Review.Nutrients · 2024Review
- Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age.BMC public health · 2024Article
- The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions.Frontiers in endocrinology · 2024Review
- Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.American journal of translational research · 2024Review
- Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products.International journal of environmental research and public health · 2022Article
- A Correlational Analysis of Phthalate Exposure and Thyroid Hormone Levels in Common Bottlenose Dolphins (Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundResearch relating either prenatal or concurrent measures of phthalate exposure to thyroid function in preschool children is inconclusive.
methodsIn a study of inner-city mothers and their children, metabolites of di-n-butyl phthalate, butylbenzyl phthalate, di-isobutyl phthalate, di(2-ethylhexyl) phthalate, and diethyl phthalate were measured in a spot urine sample collected from women in late pregnancy and from their children at age 3years. We measured children's serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) at age 3. Linear regression models were used to investigate the associations between phthalate metabolites, measured in maternal urine during late pregnancy and measured in child urine at age 3 and thyroid function measured at age 3.
resultsMean concentrations (ranges) were 1.42ng/dL (1.02-2.24) for FT4, and 2.62uIU/mL (0.61-11.67) for TSH. In the children at age 3, among girls, FT4 decreased with increasing log
conclusionsThe data show inverse and sex specific associations between specific phthalate metabolites measured in children at age 3 and thyroid function in preschool children. These results may provide evidence for the hypothesis that reductions in thyroid hormones mediate associations between early life phthalate exposure and child cognitive outcomes.
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