Evidence map›Paper›PMID 28553958›Full record

ArticleNature genetics2017

Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis.

Kazuyoshi Ishigaki, Yuta Kochi, Akari Suzuki, Yumi Tsuchida, Haruka Tsuchiya, Shuji Sumitomo, Kensuke Yamaguchi, Yasuo Nagafuchi, Shinichiro Nakachi, Rika Kato and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kazuyoshi IshigakiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yuta KochiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yumi TsuchidaDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Haruka TsuchiyaDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Shuji SumitomoDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Kensuke YamaguchiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yasuo NagafuchiDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Shinichiro NakachiDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Rika KatoDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Keiichi SakuraiDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Hirofumi ShodaDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Katsunori IkariCREST, Japan Science and Technology Agency, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9066-2005
Atsuo TaniguchiInstitute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Hisashi YamanakaInstitute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Fuyuki MiyaCREST, Japan Science and Technology Agency, Tokyo, Japan.
Tatsuhiko TsunodaCREST, Japan Science and Technology Agency, Tokyo, Japan.
Yukinori OkadaLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Ryo YamadaLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Keishi FujioDepartment of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence suggests that a substantial portion of complex disease risk alleles modify gene expression in a cell-specific manner. To identify candidate causal genes and biological pathways of immune-related complex diseases, we conducted expression quantitative trait loci (eQTL) analysis on five subsets of immune cells (CD4

Indexed as

Multifactorial InheritanceAdultAllelesArthritis, RheumatoidAsian PeopleAutoimmune DiseasesCytokinesFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansImmune SystemInflammationMaleModels, GeneticCytokines

Identifiers

PMID28553958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.