ArticleNature immunology2017
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
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In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in theFrontiers in immunology · 2023Pooled it
- Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.Frontiers in endocrinology · 2020Pooled it
- Phenome-wide association studies across large population cohorts support drug target validation.Nature communications · 2018Pooled it
- IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease.Human genetics · 2021Trial
- ProtectiveiScience · 2026Article
- Divergent cis-regulatory haplotypes at Tlr2 are associated with immune responsiveness.Molecular biology and evolution · 2026Article
- CRISPR/Cas9-Mediated Knockout of CGNL1 Confers Resistance to Aflatoxin B1 in Porcine Intestinal Epithelial Cells via Suppressing ROS Generation.International journal of molecular sciences · 2026Article
- Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans.PLoS genetics · 2026Article
- Mouse models of type I interferonopathies.Human molecular genetics · 2025Review
- Article
- Molecular basis of autoimmune disease protection by MDA5 variants.Cell reports · 2025Article
- MDA5 variants trade antiviral activity for protection from autoimmune disease.BMC medical genomics · 2025Article
- ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy.bioRxiv : the preprint server for biology · 2025Article
- MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- RNA sensing at the crossroads of autoimmunity and autoinflammation.RNA (New York, N.Y.) · 2025Review
- The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis.Frontiers in endocrinology · 2025Review
- Established and Emerging Roles of DEAD/H-Box Helicases in Regulating Infection and Immunity.Immunological reviews · 2025Review
- MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients.Clinical reviews in allergy & immunology · 2024Review
- The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expression.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Identifying Common Genetic Etiologies Between Inflammatory Bowel Disease and Related Immune-Mediated Diseases.Biomedicines · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Jacquelyn A GormanCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Christian HundhausenBenaroya Research Institute, Seattle, Washington, USA.
John S ErrettCenter for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, USA.
Amy E StoneCenter for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-9140-6510
Eric J AllenspachCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID http://orcid.org/0000-0001-7346-5835
Yan GeGenetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.ORCID http://orcid.org/0000-0003-2129-9438
Tanvi ArkatkarCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Courtnee CloughCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Xuezhi DaiCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Socheath KhimCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Kathleen PestalDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Denny LiggittDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Karen CerosalettiBenaroya Research Institute, Seattle, Washington, USA.
Daniel B StetsonDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Richard G JamesCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Mohamed OukkaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Patrick ConcannonGenetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
Michael GaleCenter for Innate Immunity and Immune Disease, University of Washington, Seattle, Washington, USA.
Jane H BucknerBenaroya Research Institute, Seattle, Washington, USA.
David J RawlingsCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Seattle Children's Hospital · USUniversity of Washington · USBenaroya Research InstituteUniversity of Florida · US
Funding
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MUnlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCWEENEY, SHANNON K. · 2012 to 2021
$36.6MWest Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 2009 to 2018
$22.5MTRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0MIntracellular nucleic acid detection in autoimmunityR01AI084914 · NIAID · UNIVERSITY OF WASHINGTON · PI STETSON, DANIEL B · 2010 to 2024
$7.2MRESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6MDiseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3MSUSCEPTIBILITY GENES IN TYPE I DIABETESR01DK046635 · NIDDK · UNIVERSITY OF VIRGINIA · PI CONCANNON, PATRICK · 1993 to 2013
$5.4MAn integrated strategy to define the functional and synergistic impact of T1D causal variantsDP3DK111802 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2016 to 2016
$4.4MDefining the functional impact of T1D genes in mouse and man: a unified strategyDP3DK097672 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2013
$4.4MInnate Immune Control of West Nile VirusR01AI104002 · NIAID · UNIVERSITY OF WASHINGTON · PI DIAMOND, MICHAEL S, GALE, MICHAEL · 2013 to 2017
$3.7MThe Host Response to Hepatitis C VirusR01AI060389 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GALE, MICHAEL · 2003 to 2012
$3.4MNIAID NIH HHS R01 AI060389NIAID NIH HHS R01 AI084914NIAID NIH HHS R01 AI104002NIAID NIH HHS R01 AI118916NIAID NIH HHS R01 AI127463NIAID NIH HHS R21 AI124735NIAID NIH HHS T32 AI007509NIAID NIH HHS U19 AI083019NIAID NIH HHS U19 AI100625NIAMS NIH HHS T32 AR007108NIDDK NIH HHS DP3 DK097672NIDDK NIH HHS DP3 DK111802NIDDK NIH HHS R01 DK046635NIDDK NIH HHS R01 DK106718NIGMS NIH HHS T32 GM007270NIH HHS P51 OD010425
Abstract
The single-nucleotide polymorphism rs1990760 in the gene encoding the cytosolic viral sensor IFIH1 results in an amino-acid change (A946T; IFIH1
Indexed as
AdolescentAdultAnimalsAutoimmune DiseasesAutoimmunityBlotting, SouthernCardiovirus InfectionsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Encephalomyocarditis virusFemaleGenetic Predisposition to DiseaseHEK293 CellsHumansImmunoblottingInterferon-Induced Helicase, IFIH1IFIH1 protein, humanIfih1 protein, mouseInterferon-Induced Helicase, IFIH1Interferon Type I
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