ArticleNature chemical biology2017
Functional selectivity of GPCR-directed drug action through location bias.
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In one paragraph
Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
149 citing papers in PubMed, 241 citations in OpenAlex.
- Inhibitory probes for spatiotemporal analysis of GαNature chemical biology · 2026Article
- AKAP6β-a conductor in the orchestra of pathological cardiomyocyte gene transcription.Molecular pharmacology · 2026Review
- Development of pH-Sensitive β‑Adrenergic Receptor Antagonists.ACS pharmacology & translational science · 2026Article
- Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Technologies to measure and modulate protein subcellular localization.Nature reviews. Molecular cell biology · 2026Review
- Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation.Journal of the American Chemical Society · 2026Article
- G protein GαThe Journal of biological chemistry · 2026Article
- Location-biased β-arrestin conformations direct GPCR signaling.Science signaling · 2026Article
- Differential conservation analysis identifies residues defining constitutive internalization in beta-adrenergic receptors.iScience · 2026Article
- β-Adrenergic Receptors: Not Always Outside-In.Physiology (Bethesda, Md.) · 2026Review
- Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors.Medicinal research reviews · 2026Review
- Conformational biosensors delineate endosomal G protein regulation by GPCRs.Nature communications · 2026Article
- Sensitive and Selective Next-Generation FRET-based PKA Biosensors.bioRxiv : the preprint server for biology · 2026Article
- Localization, trafficking, and signaling of trace amine-associated receptor 2 in mouse neuroblastoma cells.Cellular signalling · 2026Article
- An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function.bioRxiv : the preprint server for biology · 2026Article
- A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.Molecular metabolism · 2026Article
- Mechanisms of Location Bias in G Protein-Coupled Receptors.Handbook of experimental pharmacology · 2026Review
- Drug-assisted synthesis of copper nanoparticles and their induction of cuproptosis and necrosis for breast cancer therapy.Journal of Zhejiang University. Science. B · 2025Article
- The beta1-adrenergic receptor in the heart.Cell death discovery · 2025Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Roshanak IrannejadDepartment of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
Veronica PessinoDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
Delphine MikaCenter for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, San Francisco, California, USA.
Bo HuangDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
Philip B WedegaertnerDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Marco ContiCenter for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, San Francisco, California, USA.
Mark von ZastrowDepartment of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USThomas Jefferson University · US
Funding
The Presynaptic Vesicle Cycle for the Slow Acting Neurotransmitter SecretionP01DA010154 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KREITZER, ANATOL, SULZER, DAVID · 1995 to 2016
$14.7MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MPROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9MMembrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6MPALMITOYLATION AND TARGETING OF G PROTEINSR01GM056444 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WEDEGAERTNER, PHILIP B · 1998 to 2016
$4.2MMEMBRANE TRAFFICKING OF OPIOID RECEPTORSR37DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2004 to 2013
$3.1MRole of endocytosis in beta-adrenergic receptors signaling in cardiomyocytesR00HL122508 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IRANNEJAD, ROSHANAK · 2017 to 2019
$747kMultimerized GFP probe for live cell imagingR21EB022798 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, BO · 2016 to 2017
$436kMEMBRANE TRAFFICKING OF OPIOID RECEPTORSR29DA010711 · NIDA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VON ZASTROW, MARK E. · 1997 to 2003
$413kMembrane Targeting of G ProteinsR56GM056444 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WEDEGAERTNER, PHILIP B · 2007 to 2007
$271kRole of endocytosis in beta-adrenergic receptors signaling in cardiomyocytesK99HL122508 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IRANNEJAD, ROSHANAK · 2014 to 2015
$269kNHLBI NIH HHS K99 HL122508NHLBI NIH HHS R00 HL122508NIBIB NIH HHS R21 EB022798NIDA NIH HHS P01 DA010154NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIDA NIH HHS R29 DA010711NIDA NIH HHS R37 DA010711NIGMS NIH HHS R01 GM056444NIGMS NIH HHS R56 GM056444NIGMS NIH HHS T32 GM008284
Abstract
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β
Indexed as
Adrenergic beta-AntagonistsDobutamineEpinephrineGolgi ApparatusHeLa CellsHumansLigandsReceptors, Adrenergic, beta-1Structure-Activity RelationshipAdrenergic beta-AntagonistsDobutamineEpinephrineLigandsReceptors, Adrenergic, beta-1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.