ArticleNature neuroscience2017
The cellular mechanism for water detection in the mammalian taste system.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 131 citations in OpenAlex.
- A learned oral signal drives long-lasting thirst satiation.bioRxiv : the preprint server for biology · 2026Article
- Review
- Taste disorders in cancer patients and current therapeutic approaches: a narrative review of an understudied topic in supportive care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.NPJ science of food · 2025Article
- Thermoregulatory, physiological, and intestinal responses to functional waters in heat-stressed rats.Veterinary world · 2025Article
- Neurochemical Aspects of the Role of Thirst in Body Fluid Homeostasis and Their Significance in Health and Disease: A Literature Review.International journal of molecular sciences · 2025Review
- What's the occasion? Phasic dopamine signaling and interoception.Current opinion in neurobiology · 2025Review
- Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.Life (Basel, Switzerland) · 2025Review
- Influence of Water Delivery Method on the Gut Microbiome in Laboratory Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Understanding of Thirst in Medical Science.Yonago acta medica · 2025Review
- Receptors and signaling for sour and salty: the ionic taste qualities.Chemical senses · 2025Review
- Neuronal Sequences and dynamic coding of water-sucrose categorization in rat gustatory cortices.iScience · 2024Article
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Mathematical analysis and control optimization of soluble and insoluble water pollutants dispersion.Heliyon · 2024Article
- Sensory cues, behavior and fur-based drying in the rat wetness response.Scientific reports · 2024Article
- Trigeminal innervation and tactile responses in mouse tongue.Cell reports · 2024Article
- Fluid transitions.Neuropharmacology · 2024Review
- Decreased Tongue-Lip Motor Function in Japanese Population with Low Taste Sensitivity: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number.Psychopharmacology · 2024Review
- Physiological Integration of Taste and Metabolism.The New England journal of medicine · 2024Review
25 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Initiation of drinking behavior relies on both internal state and peripheral water detection. While central neural circuits regulating thirst have been well studied, it is still unclear how mammals recognize external water. Here we show that acid-sensing taste receptor cells (TRCs) that were previously suggested as the sour taste sensors also mediate taste responses to water. Genetic silencing of these TRCs abolished water-evoked responses in taste nerves. Optogenetic self-stimulation of acid-sensing TRCs in thirsty animals induced robust drinking responses toward light even without water. This behavior was only observed when animals were water-deprived but not under food- or salt-depleted conditions, indicating that the hedonic value of water-evoked responses is highly internal-state dependent. Conversely, thirsty animals lacking functional acid-sensing TRCs showed compromised discrimination between water and nonaqueous fluids. Taken together, this study revealed a function of mammalian acid-sensing TRCs that provide a cue for external water.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.