Evidence map›Paper›PMID 28553937›Full record

ArticleNature cell biology2017

Stem cell plasticity enables hair regeneration following Lgr5

Joerg D Hoeck, Brian Biehs, Antonina V Kurtova, Noelyn M Kljavin, Felipe de Sousa E Melo, Bruno Alicke, Hartmut Koeppen, Zora Modrusan, Robert Piskol, Frederic J de Sauvage

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 81 citations in OpenAlex.

  1. An updated guide to hair follicle stem cell markers and changes in their expression with aging.JID innovations : skin science from molecules to population health · 2026
    Review
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  5. Review
  6. Peptide CyZoological research · 2024
    Article
  7. Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024
    Review
  8. Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Myc-dependent dedifferentiation of Gata6Nature cell biology · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Joerg D HoeckDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Brian BiehsDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Antonina V KurtovaDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Noelyn M KljavinDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Felipe de Sousa E MeloDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Bruno AlickeDepartment of Translational Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Hartmut KoeppenDepartment of Research Pathology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Zora ModrusanDepartment of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Robert PiskolDepartment of Bioinformatics and Computational Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Frederic J de SauvageDepartment of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Molecular Oncology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Under injury conditions, dedicated stem cell populations govern tissue regeneration. However, the molecular mechanisms that induce stem cell regeneration and enable plasticity are poorly understood. Here, we investigate stem cell recovery in the context of the hair follicle to understand how two molecularly distinct stem cell populations are integrated. Utilizing diphtheria-toxin-mediated cell ablation of Lgr5

Indexed as

Cell PlasticityCell ProliferationRegenerationAlopeciaAnimalsAntigens, CD34Anti-Inflammatory AgentsBone Morphogenetic ProteinsDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHair FollicleInflammation MediatorsMaleMice, KnockoutPhenotypeAntigens, CD34Anti-Inflammatory AgentsBone Morphogenetic ProteinsInflammation MediatorsLgr5 protein, mouseReceptors, G-Protein-Coupled

Identifiers

PMID28553937
OpenAlexW2618797847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.