ArticleeLife2017
Erythropoietin signaling regulates heme biosynthesis.
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Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Milestones in the Elucidation of Heme Biosynthesis.Chemical reviews · 2026Review
- scSHEFT enables multiomics label transfer from scRNA-seq to scATAC-seq through dual alignment.Genome research · 2026Article
- Mitochondrial dysfunction-induced hemolysis: a precursor to vascular leakage and pulmonary hypertension.Blood vessels, thrombosis & hemostasis · 2025Article
- Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation.Science signaling · 2025Article
- scFocus: Detecting branching probabilities in single-cell data with SAC.Computational and structural biotechnology journal · 2025Article
- Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations.International journal of molecular sciences · 2024Article
- Role of Erythropoiesis-Stimulating Agents in Cardiovascular Protection in CKD Patients: Reappraisal of Their Impact and Mechanisms.Cardiovascular drugs and therapy · 2023Review
- PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.Nature communications · 2023Article
- Article
- Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.bioRxiv : the preprint server for biology · 2023Article
- Iron Metabolism in the Disorders of Heme Biosynthesis.Metabolites · 2022Review
- Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology.International journal of molecular sciences · 2022Review
- New Avenues of Heme Synthesis Regulation.International journal of molecular sciences · 2022Review
- Transcriptomic analysis of functional diversity of human umbilical cord blood hematopoietic stem/progenitor cells in erythroid differentiation.International journal of hematology · 2022Article
- Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria.Frontiers in cell and developmental biology · 2022Review
- Prime Real Estate: Metals, Cofactors and MICOS.Frontiers in cell and developmental biology · 2022Review
- Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins.Frontiers in cell and developmental biology · 2022Review
- Regulatory association of long noncoding RNAs and chromatin accessibility facilitates erythroid differentiation.Blood advances · 2021Article
- Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay.Metabolites · 2021Review
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Jacky ChungDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Johannes G WittigDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0002-0598-2897
Alireza GhamariDivision of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Manami MaedaDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Tamara A DaileyDepartment of Microbiology, University of Georgia, Athens, United States.
Hector BergoniaDivision of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, United States.
Martin D KafinaDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Emma E CoughlinGenome Center of Wisconsin, Madison, United States.
Catherine E MinogueDepartment of Chemistry, University of Wisconsin-Madison, Madison, United States.
Alexander S HebertGenome Center of Wisconsin, Madison, United States.
Liangtao LiDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, United States.
Jerry KaplanDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, United States.
Harvey F LodishWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, United States.
Daniel E BauerDivision of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Stuart H OrkinDivision of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Alan B CantorDivision of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Takahiro MaedaDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
John D PhillipsDivision of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, United States.
Joshua J CoonGenome Center of Wisconsin, Madison, United States.
David J PagliariniDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-0001-0087
Harry A DaileyDepartment of Microbiology, University of Georgia, Athens, United States.
Barry H PawDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0002-0492-1419
Brigham and Women's Hospital · USBoston Children's Hospital · USUniversity of Utah · USUniversity of Wisconsin–Madison · USEnergy Center of Wisconsin · USUniversity of Georgia · USUniversity of East Anglia · GBWhitehead Institute for Biomedical Research · US
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI YIEN, YVETTE Y · 1985 to 2021
$38.9MResearch Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6MTR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1MProteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6MThe Genetic Analysis of Mitochondrial Iron MetabolismR01DK052380 · NIDDK · UNIVERSITY OF UTAH · PI WARD, DIANE MCVEY · 1998 to 2016
$5.6MRegulation of Mitochondrial Metabolism by Post-Translational ModificationsR01DK098672 · NIDDK · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2013 to 2026
$4.8MRegulation of Iron HomeostasisR01DK090257 · NIDDK · UNIVERSITY OF UTAH · PI PHILLIPS, JOHN DEARBORN · 2010 to 2014
$1.8MFrascati: mitochondrial transporter and erythropoiesisR01DK070838 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI PAW, BARRY H · 2007 to 2011
$1.8MErythroid heme synthesis regulation via the ferrochelatase [2Fe-2S] clusterR01DK096051 · NIDDK · UNIVERSITY OF GEORGIA · PI DAILEY, HARRY A · 2012 to 2015
$1.5MSystematic functional annotation of the mitochondrial proteomeR01GM115591 · NIGMS · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI PAGLIARINI, DAVID J · 2016 to 2018
$1.1MEpigenetic regulation of BCL11A in the hemoglobin switchK08DK093705 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BAUER, DANIEL EVAN · 2012 to 2016
$679kNegative Electron Transfer Dissociation for Phospho-Histidine AnalysisR01GM114122 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2015 to 2016
$463kNHLBI NIH HHS P01 HL032262NIDDK NIH HHS K08 DK093705NIDDK NIH HHS L30 DK096501NIDDK NIH HHS R01 DK052380NIDDK NIH HHS R01 DK070838NIDDK NIH HHS R01 DK090257NIDDK NIH HHS R01 DK096051NIDDK NIH HHS R01 DK098672NIDDK NIH HHS R56 DK105001NIDDK NIH HHS U54 DK110858NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R01 GM114122NIGMS NIH HHS R01 GM115591NLM NIH HHS T15 LM007359
Abstract
Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown. Here, using zebrafish, murine, and human models, we show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target,
Indexed as
Signal TransductionA Kinase Anchor ProteinsAnimalsCyclic AMP-Dependent Protein KinasesErythropoietinGATA1 Transcription FactorHemeHumansMiceMitochondrial MembranesZebrafishA Kinase Anchor ProteinsCyclic AMP-Dependent Protein KinasesErythropoietinGATA1 Transcription FactorHemeAKAPdevelopmental biologyerythropoiesisferrochelatasehuman biologymedicinemousePKAporphyriastem cellszebrafish
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.