Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Potential TMS biomarkers for GABAAlcohol, clinical & experimental research · 2025Pooled it
- Laser acupuncture improves cortical excitability and behavioural performance in healthy individuals: a randomized controlled trial.BMC complementary medicine and therapies · 2026Trial
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- TMS-EEG evidence links random exploration to inhibitory mechanisms in the dorsolateral prefrontal cortex.Scientific reports · 2025Article
- A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients.Molecular psychiatry · 2025Article
- Neural Circuitry-Related Biomarkers for Drug Development in Psychiatry: An Industry Perspective.Advances in neurobiology · 2024Review
- Pharmacological mechanisms of interhemispheric signal propagation: a TMS-EEG study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study.Human brain mapping · 2019Article
- Fatigue-related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise.The Journal of physiology · 2018Article
- Pharmacological Modulation of Long-Term Potentiation-Like Activity in the Dorsolateral Prefrontal Cortex.Frontiers in human neuroscience · 2018Article
- Accelerated Repetitive Transcranial Magnetic Stimulation to Treat Major Depression: The Past, Present, and Future.Harvard review of psychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical inhibition (CI) occurs largely through GABA receptor-mediated inhibitory neurotransmission, which can be modulated by cholinergic, dopaminergic, and glutamatergic inputs. Transcranial magnetic stimulation (TMS) can be used to index CI through a paradigm known as long-interval CI (LICI). When TMS is combined with electroencephalography (EEG), LICI can index GABA receptor-mediated inhibitory neurotransmission in the dorsolateral prefrontal cortex (DLPFC). We conducted a hypothesis-driven pharmacological study to assess the role of cholinergic, dopaminergic, GABAergic, and glutamatergic neurotransmission on LICI from the DLPFC using TMS-EEG. In this randomized controlled, double-blind crossover within-subject study, 12 healthy participants received five sessions of LICI to the DLPFC in a random order, each preceded by the administration of placebo or one of the four active drugs. LICI was assessed after each drug administration and compared to LICI after placebo. Relative to placebo, baclofen resulted in a significant increase in LICI, while rivastigmine resulted in a significant decrease in LICI. Dextromethorphan and L-DOPA did not result in a significant change in LICI relative to placebo. Our study confirms that LICI in the DLPFC is largely mediated by GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.