Evidence map›Paper›PMID 28553506›Full record

ArticleChemical science2017

Selective N-terminal functionalization of native peptides and proteins.

Diao Chen, Maria M Disotuar, Xiaochun Xiong, Yuanxiang Wang, Danny Hung-Chieh Chou

Abstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Enzyme-Assisted Synthesis and In Vitro Characterization of Bifunctional PCSK9 Inhibitors.Chembiochem : a European journal of chemical biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Bioinspired Synthesis of Allysine for Late-Stage Functionalization of Peptides.Angewandte Chemie (International ed. in English) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. ACS central science · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diao ChenDepartment of Biochemistry , University of Utah , 15 N. Medical Drive East 4100 , Salt Lake City , UT 84112 , USA . Email: dchou@biochem.utah.edu.
Maria M DisotuarDepartment of Biochemistry , University of Utah , 15 N. Medical Drive East 4100 , Salt Lake City , UT 84112 , USA . Email: dchou@biochem.utah.edu.
Xiaochun XiongDepartment of Biochemistry , University of Utah , 15 N. Medical Drive East 4100 , Salt Lake City , UT 84112 , USA . Email: dchou@biochem.utah.edu.
Yuanxiang WangDepartment of Biochemistry , University of Utah , 15 N. Medical Drive East 4100 , Salt Lake City , UT 84112 , USA . Email: dchou@biochem.utah.edu.
Danny Hung-Chieh ChouDepartment of Biochemistry , University of Utah , 15 N. Medical Drive East 4100 , Salt Lake City , UT 84112 , USA . Email: dchou@biochem.utah.edu.ORCID 0000-0001-9110-614X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an efficient, highly selective modification on the N-terminal amines of peptides and proteins using aldehyde derivatives

Identifiers

PMID28553506
PMCPMC5426342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.