Evidence map›Paper›PMID 28553486›Full record

ArticleChemical science2017

Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.

Yiwu Zheng, Zhuoru Li, Jing Ren, Weidong Liu, Yaqi Wu, Yibing Zhao, Chuanliu Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  9. Approaches for peptide and protein cyclisation.Organic & biomolecular chemistry · 2021
    Review
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  11. Review
  12. Article
  13. Chemical science · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yiwu ZhengThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Zhuoru LiThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Jing RenThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Weidong LiuThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Yaqi WuThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Yibing ZhaoThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.
Chuanliu WuThe MOE Key Laboratory of Spectrochemical Analysis and Instrumentation , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , P.R. China . Email: chlwu@xmu.edu.cn.ORCID 0000-0003-2946-7299
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disulfide-rich peptides are emerging as potential templates for drug design applications. However, the synthesis and reengineering of disulfide-rich peptides are challenging, owing to the complexity of the oxidative folding process involving a number of diverse isomeric structures. Novel disulfide-rich peptide scaffolds that are not besieged by their disulfide isomers are still greatly desired. In this work, we report the design and synthesis of a novel class of artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers. In theory, natural peptides with three disulfide bonds have 15 possible isomers. By rationally engineering the thiol-framework of a peptide containing six cysteines with penicillamines and a dithiol amino acid, we demonstrated, for the first time, that the total number of isomers formed after oxidative folding can be decreased to a minimum of two (

Identifiers

PMID28553486
PMCPMC5431680
OpenAlexW2588699517

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.