ArticleChemical science2017
Visualization of drug delivery processes using AIEgens.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 88 citations in OpenAlex.
- Vascularized Tumor-on-a-Chip Model as a Platform for Studying Tumor-Microenvironment-Drug Interaction.Macromolecular bioscience · 2025Review
- Chondroitin Sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-Guided Chemotherapy Against Triple-Negative Breast Primary and Lung Metastatic Cancer.International journal of nanomedicine · 2022Article
- Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System.Molecules (Basel, Switzerland) · 2021Review
- Modulation of Aggregation-Induced Emission by Excitation Energy Transfer: Design and Application.Topics in current chemistry (Cham) · 2021Review
- Recent advances in construction of small molecule-based fluorophore-drug conjugates.Journal of pharmaceutical analysis · 2020Review
- Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics.Nano-micro letters · 2020Review
- Nanoparticle-based Cell Trackers for Biomedical Applications.Theranostics · 2020Review
- Synthesis of fluorescent polycarbonates with highly twistedRSC advances · 2019Article
- On the encapsulation and assembly of anticancer drugs in a cooperative fashion.Chemical science · 2019Article
- An AIEgen-based 3D covalent organic framework for white light-emitting diodes.Nature communications · 2018Article
- Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water.Chemical science · 2018Article
- Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process.Chemical science · 2018Article
- Exploring the trans-membrane dynamic mechanisms of single polyamidoamine nano-drugsRSC advances · 2018Article
- Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics.Chemical Society reviews · 2018Review
- Theranostics based on AIEgens.Theranostics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug delivery systems (DDSs) have been extensively studied as carriers to deliver small molecule chemo-drugs to tumors for cancer therapy. The therapeutic efficiency of chemo-drugs is crucially dependent on the effective drug concentrations in tumors and cancer cells. Novel DDSs that can simultaneously unveil drug distribution, drug release/activation behaviors and offer early evaluation of their therapeutic responses are highly desirable. Traditional fluorescent dye-labeled DDSs may suffer from notorious aggregation-caused quenching (ACQ) with limited sensitivity for bioimaging; in addition, the intrinsic fluorescence of these dyes requires careful selection of energy acceptor or quencher moieties for a light-up probe design, which complicates the development of self-reporting DDSs, especially the ones for reporting multiple processes. The recently emerged fluorogens with aggregation-induced emission characteristics (AIEgens) offer a straightforward solution to tackle this challenge. Thanks to the unique properties of AIEgens, new theranostic DDSs have been developed for simultaneous drug delivery and bioimaging with high signal to background ratio and multiple signal reporting capabilities. In this mini-review, we summarize the recent development of theranostic DDSs based on AIEgens for monitoring the drug distribution, drug activation and prediction of the therapeutic responses. Through illustration of their design principles and application examples, we hope to stimulate the interest in the design of more advanced theranostic DDSs for biomedical research.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.