ReviewNeural regeneration research2017
The reasons for end-to-side coaptation: how does lateral axon sprouting work?
Review in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment options for digital nerve injury: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits.Nature communications · 2026Article
- Extracellular matrix-modified helix-flexible nerve conduit with optimal mechanics and nerve regenerating properties.Materials today. Bio · 2025Article
- Optimizing Peripheral Nerve Regeneration: Surgical Techniques, Biomolecular and Regenerative Strategies-A Narrative Review.International journal of molecular sciences · 2025Review
- End-to-Side vs. Free Graft Nerve Reconstruction-Experimental Study on Rats.International journal of molecular sciences · 2023Article
- Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries.Journal of clinical medicine · 2023Review
- Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs.Science advances · 2022Article
- Facial reanimation with interposition nerve graft or masseter nerve transfer: a comparative retrospective study.Neural regeneration research · 2022Article
- Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function.Bioactive materials · 2022Article
- Article
- Stimulation of Neurite Outgrowth Using Autologous NGF Bound at the Surface of a Fibrous Substrate.Biomolecules · 2021Article
- Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes.The ocular surface · 2021Review
- Animal models used to study direct peripheral nerve repair: a systematic review.Neural regeneration research · 2020Article
- Aligned fibers enhance nerve guide conduits when bridging peripheral nerve defects focused on early repair stage.Neural regeneration research · 2019Article
- Reinnervation of spinal cord anterior horn cells after median nerve repair using transposition with other nerves.Neural regeneration research · 2019Article
- The role of peripheral nerve surgery in a tissue reinnervation.Chinese neurosurgical journal · 2019Review
- Supermicrosurgery: History, Applications, Training and the Future.Frontiers in surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve fibers are attracted by sutureless end-to-side nerve coaptation into the recipient nerve. Opening a window in the epineurium enhances axon attraction and myelination. The authors analyze the features of nerve repair by end-to-side coaptation. They highlight the known mechanisms of axon sprouting and different hypotheses of start up signals (presence or absence of an epineurial window, role of Schwann cells, signaling from the distal trunk). The clinical literature is also presented and differences between experimental and clinical applications are pointed out. The authors propose their point of view and perspectives deriving from recent experimental and clinical experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.