ArticleFrontiers in immunology2017
Fifth Percentile Cutoff Values for Antipneumococcal Polysaccharide and Anti-
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Quantitative Methods for Evaluating Antibody Responses to Pneumococcal Vaccines: A Scoping Review.Tropical medicine and infectious disease · 2025Review
- Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome.Journal of clinical immunology · 2024Article
- Pneumococcal IgG Antibody Responses to 23vPPV in Healthy Controls Using an Automated ELISA.Journal of clinical immunology · 2022Article
- Pneumococcal Conjugate Vaccination Followed by Pneumococcal Polysaccharide Vaccination in Lung Transplant Candidates and Recipients.Transplantation direct · 2020Article
- Defining Polysaccharide Antibody Deficiency: Measurement of Anti-Pneumococcal Antibodies and Anti-Salmonella typhi Antibodies in a Cohort of Patients with Recurrent Infections.Journal of clinical immunology · 2020Article
- Typhim vi immunization assists to discriminate primary antibody responses in hematological malignancies.MethodsX · 2020Article
- Interlaboratory variability in multiplexed pneumococcal antibody testing.The Journal of allergy and clinical immunology · 2019Article
- Measurement of Typhim Vi IgG as a Diagnostic Tool to Determine Anti-polysaccharide Antibody Production Deficiency in Children.Frontiers in immunology · 2019Observational
- A Critical View of Specific Antibody Deficiencies.Frontiers in immunology · 2019Article
- Measurement of Typhi Vi antibodies can be used to assess adaptive immunity in patients with immunodeficiency.Clinical and experimental immunology · 2018Article
- Immunoglobulin E-an Innocent Bystander in Host Defense?Journal of clinical immunology · 2018Article
- Impact of Using Different Response Criteria for Pneumococcal Polysaccharide Vaccination for Assessment of Humoral Immune Status.Journal of clinical immunology · 2018Article
- The response to Typhi Vi vaccination is compromised in individuals with primary immunodeficiency.Heliyon · 2017Article
- Value of the Overall Pneumococcal Polysaccharide Response in the Diagnosis of Primary Humoral Immunodeficiencies.Frontiers in immunology · 2017Article
- Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a World Health Organization (WHO)-standardized enzyme-linked immunosorbent assay (ELISA) are the gold standard for diagnosis of specific polysaccharide antibody deficiency (SAD). The American Academy of Allergy, Asthma and Immunology (AAAAI) has proposed guidelines to interpret the PPV response measured by ELISA, but these are based on limited evidence. Additionally, ELISA is costly and labor-intensive. Measurement of antibody response to
objectiveTo establish cutoff values for antipneumococcal polysaccharide antibody response, anti-
methodsOne hundred healthy subjects (10-55 years) were vaccinated with PPV and
resultsApplying AAAAI criteria, 30% of healthy subjects had a SAD. Using serotype-specific fifth percentile (p5) cutoff values for postvaccination IgG and fold increase pre- over postvaccination, only 4% of subjects had SAD. One-sided 95% prediction intervals for anti-
conclusionWe establish reference cutoff values for interpretation of PPV response measured by bead-based assay, cutoff values for
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