ArticleFrontiers in microbiology2017
The Hologenome Across Environments and the Implications of a Host-Associated Microbial Repertoire.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Insights into pig resilience: the Microbiome-genetic connection.Porcine health management · 2026Review
- Microbiota discovered in scorpion venom.PloS one · 2026Article
- Symbiont-Mediated Metabolic Shift in the Sea Anemone Anthopleura elegantissima.Molecular ecology · 2025Article
- Microbial solutions to dietary stress: experimental evolution reveals host-microbiome interplay inProceedings. Biological sciences · 2025Article
- Disentangling direct vs indirect effects of microbiome manipulations in a habitat-forming marine holobiont.NPJ biofilms and microbiomes · 2024Article
- Microbial community changes correlate with impaired host fitness of Aurelia aurita after environmental challenge.Animal microbiome · 2023Article
- Rhodobacteraceae dominate the core microbiome of the sea starFrontiers in microbiology · 2023Article
- Disentangling host-microbiota complexity through hologenomics.Nature reviews. Genetics · 2022Review
- Non-invasive monitoring of multiple wildlife health factors by fecal microbiome analysis.Ecology and evolution · 2022Article
- Characterization of metagenome-assembled genomes of two endo-archaea ofFrontiers in microbiomes · 2022Article
- Experimental inheritance of antibiotic acquired dysbiosis affects host phenotypes across generations.Frontiers in microbiology · 2022Article
- Bowel Movement: Integrating Host Mobility and Microbial Transmission Across Host Taxa.Frontiers in microbiology · 2022Article
- The microbiome extends host evolutionary potential.Nature communications · 2021Review
- Gut microbiota of frugo-folivorous sifakas across environments.Animal microbiome · 2021Article
- Stabilization and optimization of host-microbe-environment interactions as a potential reason for the behavior of natal philopatry.Animal microbiome · 2021Review
- Microbiome-mediated plasticity directs host evolution along several distinct time scales.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Live biotherapeutic products: the importance of a defined regulatory framework.Experimental & molecular medicine · 2020Review
- Article
- Sources of epigenetic variation and their applications in natural populations.Evolutionary applications · 2020Article
- Interspecies Communication in Holobionts by Non-Coding RNA Exchange.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of the diverse interactions between hosts and microbes has grown profoundly over the past two decades and, as a product, has revolutionized our knowledge of the life sciences. Through primarily laboratory experiments, the current framework for holobionts and their respective hologenomes aims to decipher the underpinnings and implications of symbioses between host and microbiome. However, the laboratory setting restricts the full spectrum of host-associated symbionts as compared to those found in nature; thus, limiting the potential for a holistic interpretation of the functional roles the microbiome plays in host biology. When holobionts are studied in nature, associated microbial communities vary considerably between conditions, resulting in more microbial associates as part of the "hologenome" across environments than in either environment alone. We review and synthesize empirical evidence suggesting that hosts may associate with a larger microbial network that, in part, corresponds to experiencing diverse environmental conditions. To conceptualize the interactions between host and microbiome in an ecological context, we suggest the "host-associated microbial repertoire," which is the sum of microbial species a host may associate with over the course of its life-history under all encountered environmental circumstances. Furthermore, using examples from both terrestrial and marine ecosystems, we discuss how this concept may be used as a framework to compare the ability of the holobiont to acclimate and adapt to environmental variation, and propose three "signatures" of the concept.
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