ArticleFrontiers in microbiology2017
Differing Complex Microbiota Alter Disease Severity of the IL-10
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.Seminars in immunopathology · 2026Review
- Gut microbiota and pathobiont exposure influences disease incidence in non-obese diabetic mice.Frontiers in microbiology · 2026Article
- Biological and technical variability in mouse microbiota analysis and implications for sample size determination.Lab animal · 2026Article
- Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research.mSystems · 2025Article
- E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis.Cell reports · 2025Article
- IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy.ImmunoHorizons · 2024Article
- Effect size of delayed freezing, diurnal variation, and hindgut location on the mouse fecal microbiome.iScience · 2024Article
- Standardized Complex Gut Microbiomes Influence Fetal Growth, Food Intake, and Adult Body Weight in Outbred Mice.Microorganisms · 2023Article
- Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel disease.Frontiers in physiology · 2023Article
- Grimace scale assessment duringFrontiers in veterinary science · 2023Article
- Transfer efficiency and impact on disease phenotype of differing methods of gut microbiota transfer.Scientific reports · 2022Article
- Effects of DietaryAnimals : an open access journal from MDPI · 2022Article
- Reduced housing density improves statistical power of murine gut microbiota studies.Cell reports · 2022Article
- The gut microbiome of laboratory mice: considerations and best practices for translational research.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Review
- Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism.Communications biology · 2021Article
- Consideration of Gut Microbiome in Murine Models of Diseases.Microorganisms · 2021Review
- Health Monitoring of Laboratory Rodent Colonies-Talking about (R)evolution.Animals : an open access journal from MDPI · 2021Review
- Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface.Frontiers in microbiology · 2021Review
- Complex Microbiota in Laboratory Rodents: Management Considerations.ILAR journal · 2020Article
- Lymph Node Stromal Cells From Different Draining Areas Distinctly Regulate the Development of Chronic Intestinal Inflammation.Frontiers in immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
It is estimated that 1.4 million people in the United States suffer from Inflammatory Bowel Disease (IBD), with an overall annual health care cost of more than $1.7 billion. Although the exact etiology of this disease remains unknown, research suggests that it is a multifactorial disease associated with aberrant gastrointestinal microbial populations (dysbiosis). The C57BL/6 and C3H/HeJBir mouse strains with targeted mutations in the IL-10 gene are commonly used models to study IBD. However, anecdotally, disease phenotype can vary in severity from lab to lab. Moreover, studies using germfree and monocolonized mice have suggested that gut microbiota (GM) are critical to disease induction in these models. With recent studies suggesting variation in naturally occurring GM composition and complexity among mouse producers, we hypothesized that differences in these naturally occurring complex GM profiles may modulate disease severity in the IL-10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.