Evidence map›Paper›PMID 28553230›Full record

ArticleFrontiers in pharmacology2017

The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils.

Philippe Behe, Juliet R Foote, Adam P Levine, Craig D Platt, Janet Chou, Fernando Benavides, Raif S Geha, Anthony W Segal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Increased intracellular ClActa pharmacologica Sinica · 2022
    Article
  4. Article
  5. The function of TRP channels in neutrophil granulocytes.Pflugers Archiv : European journal of physiology · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Philippe BeheDivision of Medicine, University College LondonLondon, UK.
Juliet R FooteDivision of Medicine, University College LondonLondon, UK.
Adam P LevineDivision of Medicine, University College LondonLondon, UK.
Craig D PlattDivision of Immunology, Boston Children's Hospital, Harvard Medical School, BostonMA, USA.
Janet ChouDivision of Immunology, Boston Children's Hospital, Harvard Medical School, BostonMA, USA.
Fernando BenavidesDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, HoustonTX, USA.
Raif S GehaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, BostonMA, USA.
Anthony W SegalDivision of Medicine, University College LondonLondon, UK.

Funding

Novel mechanisms of T cell costimulation: the role of LRRC8A in T cell activationK08AI116979 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHOU, JANET · 2015 to 2019
$934k
NIAID NIH HHS K08 AI116979
6 · The paper itself

Abstract

The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl

Indexed as

chlorideion channelLRRC8ANADPH oxidaseneutrophilTamoxifenvacuolar homeostasisVSOR Cl- current

Identifiers

PMID28553230
PMCPMC5427109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.